奥沙利铂过敏反应的防治研究进展

Progress in studies on prevention and treatment of hypersensitivity induced by oxaliplatin

奥沙利铂过敏反应临床可表现为呼吸道症状、皮肤症状和其他全身症状,多发生于多疗程用药后。致敏机制可能与体内细胞因子的大量释放有关。皮肤敏感试验、降低静脉滴注速度、接受药物预处理及脱敏疗法可降低奥沙利铂过敏反应的发生风险与程度。

Clinical presentations of oxaliplatin-induced anaphylactic reaction are respiratory tract symptoms, skin symptoms and other systemic symptoms. Hypersensitivity induced by oxaliplatin usually occurs after multiple treatment courses. The mechanisms of oxaliplatin-induced anaphylactic reaction may be associated with a high cytokine release. The risk and severity of oxaliplatin-induced anaphylactie reaction can be reduced by using allergy skin test, a slower infusion rate, a conditioning regimen and desensitization therapy.