摘要
1例37岁女性人类免疫缺陷病毒感染者,因肺部感染静脉泵入头孢哌酮钠舒巴坦钠3.0 g,1次/d,第21天改为口服莫西沙星400 mg,1次/d。口服用药第3天患者出现皮肤瘙痒,第7天颜面和全身体表出现大量红色丘疹,瘙痒伴红肿,疑为药疹。停用莫西沙星,给予葡萄糖酸钙、地塞米松、氯雷他定等抗过敏药物。2 d后患者面部和躯体弥漫性分布暗红色斑片,表皮呈鳞片状,全身红肿,睁眼困难,双下肢水肿。8 d后患者面部和躯体表皮呈鳞片状脱落,瘙痒症状逐渐消退。
A 37-year-old woman with HIV received IV cefoperazone sodium and sulbactam sodium 3.0 g once daily via a pump for pulmonary infection. On day 21 , the drug therapy was changed to oral moxifloxacin 400 mg once daily. On day 3 of oral moxifloxacin therapy, the patient developed skin pruritus. On day 7, her face and entire body developed numerous red papules and skin pruritus with red swelling. Drug eruption was suspected. Moxifloxacin was stopped. Anti-allergic drugs such as calcium gluconate, dexamethasone, and loratadine were given. Two days later, she presented with diffuse dark red patch, scaly skin, generalized swelling and difficulty keeping eye open, and edema in her lower extremities. After 8 days, she had exfoliative desquamation on her face and trunk, and her pruritus gradually subsided.
出处
《药物不良反应杂志》
2012年第5期312-313,共2页
Adverse Drug Reactions Journal
关键词
皮炎
剥脱性
莫西沙星
dermatitis, exfoliative
moxifloxacin
