摘要
目的通过观察曲美他嗪对不稳定性心绞痛患者血浆N端脑钠肽前体（NT-proBNP）浓度的影响，从而判断其疗效。方法112例不稳定性心绞痛患者，随机分为对照组54例及曲美他嗪组58例，均于入院即刻，入院后1、3、7及10d抽取静脉血，测量血浆中NT-proBNP浓度。结果对照组血浆NT-proBNP浓度于入院1d后达高峰[（98647±768．38）ng／L]，曲美他嗪组入院即刻其血浆中NT-proBNP浓度与对照组差异无统计学意义（P〉005）；但经曲美他嗪治疗1、3、7及10d后血浆NT-proBNP浓度[（57239±541．43）、（54645±513．39）、（459564-42817）、（402．15±381．57）ng／L]均较对照组明显为低，差异均有统计学意义（均P〈005）。结论不稳定性心绞痛患者血浆中NT-proBNP浓度升高；曲美他嗪对不稳定性心绞痛有良好的疗效，表现为患者NT-proBNP浓度的下降。
Objective To investigate the effect of trimetazidine on serum NT-proBNP levels in patients with unstableangina. Methods One hundred and twelve patients with unstable angina （UA） were randomly divided into trimetazidine group （n=58） and control group （n=54）. The fast blood samples were obtained at d0, d1, d3, d7 and d10 and the serum NT-proBNP levels were measured. Results There was no significant difference in serum NT-proBNP levels between two groups at dO. Serum NT-proBNP levels in trimetazidine group were significantly lower than those in contro group at d1, d3, d7 and dl0 re- spectively （all P〈0.05）. Conclusion The patients with unstable angina show a higher serum NT-proBNP levels, which can be reduced by effective trimetazidine treatment.
出处
《浙江医学》
CAS
2012年第24期1971-1972,1981,共3页
Zhejiang Medical Journal
