丝裂霉素C联合粘弹剂在青光眼小梁切除术中的应用

Effect of Mitomycin C and Gluey Healon in Glaucoma Trabeculectomy

目的:探讨在青光眼小梁切除术中联合应用丝裂霉素C(mitomycin C,MMC)和粘弹剂预防术后浅前房发生的临床效果。方法:将64例青光眼患者随机分为研究组(n=32,38只眼)和对照组(n=32,37只眼)。研究组在小梁切除术中应用0.4mg/mL的MMC棉片,缝合结膜瓣前在巩膜瓣下及前房内注入少量粘弹剂(1%gluey Healon)。对照组仅应用MMC,而不用粘弹剂。结果:研究组术后有6眼发生浅前房(15.8%),对照组术后有17眼发生浅前房(45.9%),两者差异有统计学意义(P<0.05);而在远期滤过泡形成及眼压控制方面两组无显著差异。结论:在应用MMC的青光眼小梁切除术中,如联合应用粘弹剂,可以有效预防浅前房的发生而不影响远期效果。

Objective：To study the clinical effects of using mitomycin C（MMC） and gluey Healon in the glaucoma trabeculec- tomy. Methods：In the study group （32 cases, 38 eyes）, MMC flakes of 0.4 mg/mL were used in the trabeculectomy, a little of giuey Healon was iniected into anterior chamber and under scleral ilap before it was sewed. In eontrol group （ 32 cases, 37 eyes）, MMC was used, but gluey Healon was not used. Results： In the study group, there were 6 eyes （15.8%） of shallow anterior chamber after trabeculetomy; while in control group, there were 17 eyes （49.9%） of shallow anterior chamber （P〈0.05） . There was no significant difference between the two groups in the intraocular pressure and the formation of filter-bub ble in the long term. Conclusions： Using MMC in combination with gluey Healon in trabeculectomy can prevent the formation shallow anterior chamber, but long-term effect is not influenced.