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抗血小板药物的研究进展 被引量：3

Research progress of antiplatelet agent
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摘要 动脉粥样硬化血管内不稳定斑块破裂后，随之触发血小板激活和凝血酶形成，造成血栓形成。在这一病理过程中血小板的激活是启动因素，抗血小板治疗成为预防和治疗动脉系统血栓的基石。目前抗血小板药主要分4类：①影响花生四烯酸代谢的药物（阿司匹林）；⑦增高环磷酸腺苷（cAMP）水平的药物（贝前列素、西洛他唑等）；
作者 王海斌 高晓丽 王东颖
机构地区 任丘市华北石油总医院心内科
出处 《中国心血管病研究》 CAS 2013年第1期59-61,共3页 Chinese Journal of Cardiovascular Research
关键词 冠状动脉疾病 抗血小板 治疗 血栓 Coronary heart disease Antiplatelet Therapy thrombosis
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献14

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  • 2Wivioa SD,Antman EM,Gibson CM. Evaluation of prasugrel compared with elopidogrel in patients with acute coronary syndromes:design and rationale for the trial to assess improvement ifl therapeutic outcomes by optimizing platelel inhibition with prasugrel thrombolysis in myocardial infarction 38(TRITON11MI33)[J].American Heart Journal,2006.627-635.
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二级参考文献58

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共引文献17

同被引文献23

  • 1龚平,王朝晖,杜林林,刘小楣,罗丰,胡家顺.替罗非班在家兔血栓模型中对血小板聚集的影响[J].中国药学杂志,2006,41(8):593-596. 被引量：8
  • 2彭志松,叶飞,陈绍良,朱中生,张俊杰,林松.血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂治疗老年ACS的研究[J].实用老年医学,2006,20(5):331-332. 被引量：16
  • 3李瑞建,陈玉国,张运,孙祎,徐峰,吕瑞娟,纪求尚,李继福,李贵双.早期应用替罗非班对急诊冠脉介入术后心肌微循环再灌注的影响[J].中国新药与临床杂志,2007,26(3):207-211. 被引量：17
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  • 7盐酸替罗非班多中心临床协作组.盐酸替罗非班对急性冠脉综合征的疗效和安全性评价.临床心血管病杂志,2006,22:220-222.
  • 8Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med, 2009,361 : 1045-1057.
  • 9Cannon CP, Harrington RA, James S, et al. Comparison of ticagrelor with clopidogrel inpatients with a planned invasive strategy for acute coronary syndromes (PLATO):a Randomised double blind study. Lancet,2010,375:283-293.
  • 10Storey RF. Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors. Thromb Haemost, 2011,105 : S75-81.

引证文献3

二级引证文献37

中国心血管病研究
2013年 第1期

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