无抽搐电休克疗法治疗难治性抑郁疗效观察

Study on experience in treatment of refractory depression with no twitch electric shock therapy

目的探讨难治性抑郁症(TRD)的治疗方法,为临床治疗TRD提供新的治疗方案。方法选取2009年4月至2010年5月接收的60例TRD病例,将其随机分为研究组和对照组,各30例,研究组采用无抽搐电休克疗法治疗TRD,对照组采用常规抗抑郁药物治疗TRD,对比分析两组治疗TRD的治疗效果以及不良反应。结果研究组治疗后第1、2、4周的HAMD平均减分率分别25.1%、34.9%、64.9%,而对照组治疗后第1、2、4周的HAMD平均减分率分别为4.9%、8.5%、16.8%。研究组的HAMD平均减分率明显高于对照组的HAMD平均减分率。治疗结束后1周,研究组的总有效率为63.33%;对照组的总有效率为30.00%,研究组总有效率明显高于对照组。结论相比于常规药物治疗,无抽搐电休克疗法治疗TRD具有见效快、疗效好、不良反应少以及患者依从性好等诸多优点,是临床上治疗TRD安全、快速、有效的方法。

Objective To explore the treatment of refractory depression,and to provide new approach for clinical treatment of refractory depression.Methods Sixty patients with refractory depression in this hospital during April 2009 to May 2010 were randomly divided into study group and control group,each group with 30 cases.Patients in study group received no twitch electric shock therapy for treatment of their depression,and patients in control group were given with conventional therapy of antidepressant medication for treatment of refractory depression,and the effect of treatment and adverse reactions were compared between these 2 groups.Results After treatment for 1,2 and 4 weeks,HAMD average minus points in patients of study group were 25.1%,34.9% and 64.9% respectively,and the HAMD average minus points in patients of control group after treatment for 1,2 and 4 weeks were 4.9%,8.5%,16.8% respectively.The average deduction rate of HAMD in patients of study group was significantly higher than that of patients in control group.The total effective rate of patients in study group after treatment for 1 week was 63.33%,and the total effective rate of patients in control group was 30%,hence the total effective rate of patients in study group was significantly higher than that of patients in control group.Conclusion In comparison with conventional drugs,no twitch electric shock therapy in treatment of refractory depression has quicker and better efficacy and fewer side effects and many other advantages,and compliance of patients is good,hence it is a clinically safe,fast and effective method for treatment of refractory depression,and it is worthy to be clinical application.