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恩杂鲁胺 被引量:1

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摘要 恩杂鲁胺(enzalutamide)是由Medivation公司和安斯泰来(Astellas)公司合作开发,于2012年8月31日经美国食品药品管理局(FDA)批准用于治疗已扩散或复发的晚期男性去势耐受前列腺癌(castration-resistantprostatecancer),商品名为Xtandi,该药为口服制剂。
作者 刘子建 宫平
机构地区 沈阳药科大学
出处 《中国药物化学杂志》 CAS CSCD 2013年第1期79-79,共1页 Chinese Journal of Medicinal Chemistry
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参考文献6

  • 1Jung M E,Ouk S,Yoo D,et al.Structure-activity relationshipfor thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC)[].Journal of Medicinal Chemistry.2010
  • 2TRAN C,OUK S,CLEGG N,et al.Development of a second generation antiandrogen for treatment of advanced prostate cancer[].Science.2009
  • 3SAWYERS C,JUNG M,CHEN C,et al.Diarylhydantoin com-pounds[].WO.2006
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  • 5THOMPSON A,LAMBERSON C,GREENFIELD S,et al.Processes for the synthesis of diarylthiohydantoin and diarylthiohydantoin compounds[].WO.2011
  • 6JUNG M,OUK S,SAWYERS C,et al.Methods and materials for assessing prostate cancer therapies and compounds[].US.2008

同被引文献36

  • 1宋丽君,王飏,陆旭芳,李志裕.雄激素受体拮抗剂MDV3100的合成研究[J].精细化工中间体,2012,42(1):34-36. 被引量:7
  • 2崔福德.药剂学[M].北京:人民卫生出版社,2008:311-314.
  • 3TRAN C,OUK S,CLEGG N,et al. Development of a second generation antiandrogen for treatment of ad- vanced prostate cancer [J]. Science,2009,324(5928).. 787-790.
  • 4CHARLES kS,MICHAEL EJ,CHARLIE DC,et al. Di- arylhydantoin Compounds: US, 7709517 [ P ].2010-05-04.
  • 5HOWARD L SCHER,KARIM FIZAZI,FRED SAAD, et al. Increased survival with enzalutamide in prostate af- ter chemotherapy[OL]. N Engl Med: 2012-8-15.
  • 6FOSSA SD, SLEE PH, Brausi M, et al. Flutamide versus prednisone in patients with prostate cancer symptomati- cally progressing after androgen-ablative therapy: a phase III study of the European organization for re- search and treatment of cancer genitourinary group [J]. J Clin Oncol,2001,19(1 ) :62-71.
  • 7AKAZA H,HINOTSU S,USAMI M,et al. Study group for the combined androgen blockade therapy of prostate cancer combined androgen blockade with hiealutamide for advanced prostate cancer: long-term follow-up of a phase 3,double-blind,randomized study for survival [ J ]. Cancer, 2009 ; 115 ( 15 ) : 3437-3445.
  • 8CRAWFORI) E D,EISENBERGER M A,MCLEOD DG,et al. A controlled trial of leuprolide with and with- out flutamide in prostatic carcinoma[J]. N Engl J Med, 1989,321 (7) :419-424.
  • 9CHEN CD,WELSBIE DS,TRAN C,et al. Molecular determinants of resistance to antiandrogen therapy [J]. Nat Med, 2004,10( 1 ) : 33-39.
  • 10KOLVENBAG GJ,FURR BJ,BLACKLEDGE GR. Re- ceptor affinity and potency of non-steroidal antiandro- gens: translation of preclinical findings into clinical activity [J]. Prostate Cancer Prostatic Dis, 1998(6): 307-314.

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