MDM2基因SNP309多态性与白血病易感性关系的Meta分析

Association of MDM2 Gene Promoter SNP 309 Polymorphism with Leukemia Susceptibility: A Meta-Analysis of Case-Control Studies

目的系统评价小鼠双微体基因2(murine double minute 2,MDM2)启动子309位点单核苷酸多态性(single nucleotide polymorphism,SNP309)与白血病易感性的关系。方法计算机检索Ovid、EBSCO、PubMed、CNKI、CBM、VIP及WanFang Data,搜集相关病例-对照研究,检索时限为1990年1月～2012年6月。按纳入与排除标准筛选文献、提取资料并评价纳入研究的方法学质量后,采用RevMan 5.0、Stata 10.0软件进行Meta分析,计算合并OR值及其95%CI,并进行敏感性分析及发表偏倚评估。结果共纳入8篇文献9个研究,累计病例1 821例,对照5 642例。Meta分析结果显示:携带G等位基因者对于T等位基因者,白血病易感性增加[OR=1.26,95%C(I1.08,1.46),P=0.003];基因型为GG的人群白血病发病风险高于基因型为TT的人群[OR=1.46,95%C(I1.02,2.10),P=0.04];隐性模型中亚洲人GG纯合子基因型人群白血病发病风险高于GT+TT基因型人群[OR=2.00,95%CI(1.37,2.92),P=0.000 3]。未见明显发表偏倚。结论 MDM2基因SNP309多态性与白血病易感性相关,等位基因G可能是白血病易感的危险因素。

Objective To investigate the association between MDM2 gene promoter SNP 309 polymorphism and leukemia susceptibility. Methods Such databases as Ovid, EBSCO, PubMed, CNKI, CBM, VIP and WanFang Data were searched to collect the case-control studies published from January 1990 to June 2012. According to the inclusion and ex- clusion criteria, the studies were screened, the data were extracted, and the methodological quality of the included studies was evaluated. Men meta-analysis was conducted using RevMan 5.0 and Stata 10.0 software, the pooled odds ratio （ORs） with 95% confidence interval （CI） were calculated, and the sensitivity and publication bias were evaluated at the same time. Results A total of 9 studies within 8 articles were included, which involved 1 821 cases and 5 642 controls. The re- sults of meta-analysis showed that, the susceptibility of leukemia was increased in the G allele carriers compared with the T allele carriers （OR=1.26, 95%CI 1.08 to 1.46, P=0.003）, and the leukemia risk was higher in the GG genotype popula- tions compared with the TT genotype populations （OR：1.46, 95%CI 1.02 to 2.10, P=0.04）. Among Asians with recessive models, the leukemia risk was higher in the homozygous GG genotype compared with both the heterozygous GT geno- type and the homozygous TT genotype （OR=2.00, 95%CI 1.37 to 2.92, P=0.000 3）. There was no obvious publication bias. Conclusion MDM2 gene promoter SNP 309 polymorphism is associated with the susceptibility of leukemia, and the G allele is likely to be the risk factor for leukemia.