2010-2011年我院药品不良反应报告分析

analysis of reports of ADR in our hospital During the Period of 2010-2011

目的分析药品不良反应(ADR)发生的原因和特点,为临床合理用药提供参考方法对医院2010-2011年上报的233例药品不良反应报告,按患者年龄、性别、给药途径、引起ADR的药品种类、涉及器官或系统以及临床表现等进行统计、分析。结果233例ADR报告中,小于18岁的患者ADR发生率最高,为42.49%;静脉滴注是引起ADR的主要途径,占87.98%;抗菌药物ADR发生率最高,占66.52%;最常见ADR的临床表现是皮肤及其附件损害,占60.09%。结论医务人员应重视ADR的报告及监测工作,合理应用抗菌药物及静脉注射剂,重点关注特殊人群用药,减少ADR的发生,确保患者用药安全。

Objective To analyze the reasons and characteristics of the adverse drug reactions（ADR）occurred in hospital to promote rational drug use.Methods Two hundred and thirty three cases of ADR reports collected in our hospital from 2010 to 2011 were performed the statistical analysis in aspects of age,sex,route of administration,drug categories inducing ADR,involved organs or systems and the clinical manifestations etc.Results Of 233 cases of ADR reports,the patient aged less than 18 years is the largest propotion（42.49%）;87.98% were induced by intravenous injection;66.52% by antimicrobials,especially by quinolones and cephalosporins and 60.09% manifested as lesions of skin and its appendages.Conclusion Great importance should be attached to the monitoring and reporting of ADR as well as rational use of antibiotics and intravenous injections especially for drug use in special group so as to reduce the incidence of ADR and promote clinical medication safety.