输卵管结扎对卵巢癌影响的临床分析

Clinical significances of tubal ligation in ovarian cancer

目的比较卵巢癌不同病理分类、组织学分级、二元论分型中输卵管结扎的比例，了解输卵管结扎对卵巢癌的影响。方法回顾性分析2004年6月至2011年6月间在郑州大学第三附属医院妇产科就诊的89例卵巢癌患者及同期因子宫肌瘤、子宫脱垂就诊的149例患者中输卵管结扎的比例。结果卵巢浆液性癌49例，其中行输卵管结扎者13例；卵巢黏液性癌33例，其中行输卵管结扎者14例；卵巢子宫内膜样癌7例，均未行输卵管结扎。卵巢浆液性癌G1、G2、G3级中输卵管结扎的分别为6、8、1例；卵巢黏液性癌G1、G2、G3级中输卵管结扎的分别为5、6、1例；子宫内膜样癌G1、G2、G3级分别为3、2、2例（均未行输卵管结扎）；二元论分型Ⅰ型中输卵管结扎5例；Ⅱ型中输卵管结扎22例；卵巢癌组、对照组中输卵管结扎〈5年者分别为15、29例，5—10年者分别为10、26例，〉10年者分别为2、4例；卵巢癌中输卵管结扎比例低于对照组；卵巢癌G3组输卵管结扎比例低于非G3组；随着输卵管结扎年限的增长，卵巢癌中输卵管结扎比例差异有统计学意义（P〈0．05）。结论输卵管结扎对卵巢癌可能有一定的影响，但输卵管结扎年限对卵巢癌并无明显影响。

Objective To compare the proportion of tubal ligation in the different pathological classifications, histological grades, dualism types of ovarian cancer, and try to understand the correlation between tubal ligation and ovarian cancer. Methods A retrospective analysis to the tubal ligation ratio in ovarian cancer patients hospitalized in the third affiliated hospital of Zhengzhou university from June 2004 to June 2011, and 149 patients hospitalized due to uterine fibroids, uterine prolapse were as control group. Results The proportion of tubal ligation in serous ovarian cancer was 13/49 ; and that in mucous ovarian cancer was 14/33 ; therefore, there was no tubal ligation in endometrial sample ovarian cancer. In serous ovarian cancer, the number of tubal ligation in different pathological classifications G1, G2, G3, was 6, 8, 1, respectively; and in mucous ovarian cancer, the number was 5, 6, 1, respectively; also in uterine endometrial carcinoma, pathological classification was G1, G2, G3 3, 2, 2 （None line of tubal ligation）. According to dualism types of ovarian cancer, there were 5 cases of rubal ligation carcinoma in type Ⅰ , and 22 cases in type Ⅱ. In the ovarian cancer group and the control group, the patients who got tubal ligation less than 5 years were 15 cases and 29 cases respectively, and the ones got tubal ligation 5 - 10 years were 10 cases and 26 cases respectively, and the ones more than 10 years were 2 cases and 4 cases respectively. The data revealled that in ovarian cancer, the proportion of tubal ligation was lower than that in control group, and also the proportion of tubal ligation in ovarian cancer of G3 was lower than that in the group of G1 ＋ G2. while there was no difference between the time of tubal liga- tion and the proportion in ovarian cancer. Conclusions Tubal ligation there might be certain influence on ovarian cancer, but there is no signa6cance between the time of tubal ligation and ovarian cancer.