多烯磷脂酰胆碱联合复方甘草酸苷治疗酒精性肝病的疗效观察

Effect of polyene phosphatidyl choline combined with compound glycyrrhizin in treatment of alcoholic liver disease

目的观察多烯磷脂酰胆碱联合复方甘草酸苷治疗酒精性肝病的疗效和安全性。方法将72例酒精性肝病患者随机分为两组，对照组36例给予复方甘草酸苷治疗，治疗组36例在对照组治疗的基础上应用多烯磷脂酰胆碱治疗，疗程均为4周，观察治疗前后症状、体征和肝功能的变化，并监测药物不良反应。结果治疗组的显效率和总有效率显著高于对照组（χ^2=4．1806，P〈0．05），治疗后两组患者天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶、γ-谷氨酰基转肽酶和总胆红素均较治疗前明显降低（P均〈0．01），且治疗组天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、谷氨酰转移酶、γ-谷氨酰基转肽酶和总胆红素下降程度均显著优于对照组（t=10．589，6．8388，3．4320，3．9504，4．2626，P均〈0．01）。两组均未见明显不良反应。结论多烯磷脂酰胆碱联合复方甘草酸苷治疗酒精性肝病安全有效，优于单用复方甘草酸苷。

Objective To observe the effect and safety of polyene phosphatidyl choline combined with compound glycyrrhizin in treatment of alcoholic liver disease. Methods Seventy-two patients with alcoholic liver disease were randomly divided into two groups, 36 cases in the control group received compound giycyrrhizin therapy, 36 cases in the treatment group received polyene phosphatidyl choline on the basis of the control group. The treatment lasted four weeks in the two groups. To observe the changes in symptoms, signs and liver function（ AST, ALT, GGT, ALP, TBiL） of patients in the two groups beforeand after treatment. And to monitor adverse drug reactions. Results Apparent efficiency and total efficiency rate of the treatment group was significantly higher than that of the control group （ χ^2 = 4,4. 1806, P 〈 0.05 ）. After treatment, AST, ALT , GGT, ALP and TBiL of patients in the two groups were significantly lower than those before treatment （ P all 〈 0.01 ）. And AST, ALT, GGT, ALP and TBiL of patients in treatment group were significantly better than those in the control group （t = 10. 589,6. 8388,3. 4320,3.9504,4. 2626, P 〈 0.01 ）. Conclusions Polyene phosphatidyl choline combined with compound glycyrrhizin in treatment of alcoholic liver disease is safe and effective, is better than treat with single compound glycyrrhizin.