摘要
Polyion complex （PIC） micelles were spontaneously formed in aqueous solutions through electrostatic interaction between two oppositely charged block copolymers, poly（N-isopropylacrylamide）-b-poly（L-glutamic acid） and poly（N-isopropylacrylamide）-b-poly（L-lysine）. Their controlled synthesis was achieved via the ring opening polymerization of N-carboxyanhydrides （NCA）, ε-benzyloxycarbonyl-L-lysine （Lys（Z）-NCA） or γ-benzyl-L-glutamate （BLG-NCA） with amino-terminated poly（N-isopropylacrylamide） macroinitiator and the subsequent deprotection reaction. The formation of PIC micelles was confirmed by dynamic light scattering and transmission electron microscopy. Turbidimetric characterization suggested that the formed PIC micelles had a concentration-dependent thermosensitivity and their phase transition behaviors could be easily adjusted either by the block length of coplymers or the concentration of micelles.
Polyion complex （PIC） micelles were spontaneously formed in aqueous solutions through electrostatic interaction between two oppositely charged block copolymers, poly（N-isopropylacrylamide）-b-poly（L-glutamic acid） and poly（N-isopropylacrylamide）-b-poly（L-lysine）. Their controlled synthesis was achieved via the ring opening polymerization of N-carboxyanhydrides （NCA）, ε-benzyloxycarbonyl-L-lysine （Lys（Z）-NCA） or γ-benzyl-L-glutamate （BLG-NCA） with amino-terminated poly（N-isopropylacrylamide） macroinitiator and the subsequent deprotection reaction. The formation of PIC micelles was confirmed by dynamic light scattering and transmission electron microscopy. Turbidimetric characterization suggested that the formed PIC micelles had a concentration-dependent thermosensitivity and their phase transition behaviors could be easily adjusted either by the block length of coplymers or the concentration of micelles.
基金
financially supported by the National Natural Science Foundation of China (Nos. 20904053, 51021003,51173184)
the Ministry of Science and Technology of China (International cooperation program 2011RI0001)
the Program of the Science and Technology of Changchun (No. 2010061)
