摘要
将手性的L-谷氨酸(Glu)接枝到羧基化氧化石墨烯片层上,制备了一种羧基化氧化的氧化石墨烯-谷氨酸复合物(GeneO-Glu),提高了羧基化的氧化石墨烯的生物相容性.利用红外光谱、静态水接触角、X射线衍射及热重分析等手段对所合成的GeneO-Glu复合物进行了表征,并对其复合机理进行了探讨.结果表明,Glu可在一定条件下通过化学反应键合在羧基化的氧化石墨烯片层上.血浆复钙时间随着复合物浓度的增加而增加;不同pH值条件下合成的复合物在不同浓度下的溶血率均小于5%,GeneO-Glu复合物在低浓度时即表现出优良的抗凝血性能.
Anticoagulation properties of biomaterials are crucial for biomedical applications,especially for blood-contacting materials.Carboxylated graphene oxide complexes with L-glutamic acid was prepared.The complexes were characterized by FTIR,static contact angle（SCA）,XRD and TG.The anticoagulation properties of complexes were evaluated by hemolysis test and recalcification time test.The results show that the L-glutamic acid has been coordinated on graphene oxide sheet layer.The plasma recalcification time were prolonged greatly as compared to whole blood.At lower concentrations,the hemolysis rates was less than 5%,which met the requirements of biomedical materials.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2013年第2期479-484,共6页
Chemical Journal of Chinese Universities
基金
江苏省“六大人才高峰”高层次人才项目(批准号:NY-031)
江苏高校优势学科建设工程资助项目(批准号:PAPD)
江苏省产学研前瞻性联合研究项目(批准号:BY2011109)资助
关键词
羧基化氧化石墨烯
L-谷氨酸
溶血实验
复钙时间
Carboxylated graphene oxide
L-Glutamic acid
Hemolysis test
Plasma recalcification time
