地尔硫卓联合艾司洛尔对高血压合并急性冠状动脉综合征患者血压和心率的控制

Control of Blood Pressure and Heart Rate of Hypertension with Acute Coronary Syndrome Treated by Diltiazem Combined with Esmolol

目的研究地尔硫卓联合艾司洛尔在高血压合并急性冠状动脉综合征早期对血压和心率的影响,探讨联合用药的临床效果及安全性。方法选取我科高血压合并急性冠状动脉综合征的患者48例,随机分为观察组和对照组各24例,观察组给予地尔硫卓联合艾司洛尔治疗,对照组仅给予艾司洛尔,比较两组患者治疗前后血压、心率、心电图的变化,症状改善的时间以及24h的心率变异性。结果治疗4h后,两组患者的心率,SBP/DBP,心电图ST段压低均较治疗前有所改善;组间比较发现,观察组患者心绞痛等主观症状的改善时间明显短于对照组,且心率,SBP/DBP,心电图ST段压低等指标的改善也优于对照组(P<0.05)。结论联合用药治疗急性冠状动脉综合征见效更快,可更好的控制血压和心率,但在心率变异性的改善方面较单一用药无差别。

Objective To evaluate the effects of diltiazem combined with esmolol on blood pressure（BP） and heart rate（HR） in patients with hypertension and acute coronary syndrome（ACS）.Method 48 patients with hypertension and acute coronary syndrome were selected and divided into two groups randomly as observation group and control group.Each group contains 24 patients.The observation group received diltiazem combined with esmolol treatment while the control group received esmolol treatment.The BP,HR,ECG,and syndrome remission of all patients were observed before and after treatment.Results There was a significant difference（P0.05） in SBP/DBP,HR and ECG after the treatment in 4 hours between two groups.The observation group has better clinical effect than the control group in the respects of BP,HR,ECG,and syndrome remission.Conclusion With no more adverse reactions,diltiazem combined with esmolol is more effective in patients with acute coronary syndrome.