丙泊酚和依托咪酯在胃镜下食管静脉曲张套扎术中的应用

Application of Propofol and Etomidate in Endoscopic Esophageal Variceal Ligation

目的比较丙泊酚和依托咪酯复合利多卡因胶浆在胃镜下食管静脉曲张套扎术中的效果。方法胃镜下行食管静脉曲张套扎术的患者60例,随机分为两组,每组30例:P组静脉注射丙泊酚+口服利多卡因胶浆;E组静脉注射依托醚酯+口服利多卡因胶浆。记录两组患者入室时、置镜前、置镜时、苏醒后各时间点MAP、HR、SpO2及苏醒时间、不良反应情况。结果 P组置镜前、置镜时、苏醒后各时点的血压较入室时降低,心率较入室时慢,差异有统计学意义(P<0.05)。E组置镜前、置镜时、苏醒后各时点的血压和心率与入室时比较,差异无统计学意义(P>0.05)。两组意识完全恢复时间分别为(5.8±0.8)min,(5.9±0.9)min,差异无统计学意义(P>0.05)。结论丙泊酚和依托咪酯复合利多卡因胶浆均可用于胃镜下食管静脉曲张套扎术,两者临床效果确切,不良反应少,但在血流动力学的稳定上,依托咪酯似乎更具优势。

Objective Comparing the effects of propofol and etomidate compound lidocaine hydrochloride mucilage in endoscopic esophageal variceal ligation.Method 60 patients for endoscopic esophageal variceal ligation were divided into two groups randomly.Group P received intravenous propofol combined with oral administration of lidocaine hydrochloride mucilage.Group E received intravenous etomidate with oral administration of lidocaine hydrochloride mucilage.Had recorded mean arterial pressures,heart rates and oxygen saturations at the time of before propofol or etomidate administration,endoscopy in front,after endoscopy in and after awaking.Recovery time and adverse reaction of all patients were recorded too.Result The mean arterial pressure and heart rate of group P at the time of endoscopy in front,after endoscopy in and after awaking decreased significantly than before propofol administration（P0.05）.Recovery time of group P and E were（5.8±0.8）min and（5.9±0.9）min,there was no difference（P0.05）.Conclusion Propofol and etomidate compound lidocaine hydrochloride mucilage can be used in endoscopic esophageal variceal ligation,they are safety and effective,but etomidate is better an propofol in hemodynamic stability.