Graves'病^(131)I治疗对IL-2、IL-6和TNF-α细胞因子的影响

Changes of IL-2, IL-6, TNF Concentration After ^(131)I Therapy in Patients with Hyperthyroidism from Graves’ Disease

目的通过对131I治疗前后Graves’病患者血清IL-2、IL-6和TNF-α细胞因子水平的比较,探讨细胞因子与Graves病发生、发展的内在联系。方法放射免疫分析法检测45例接受131I治疗的GD患者治疗前后60d外周血清IL-2、IL-6和TNF-α浓度变化,分析其与血清甲状腺激素水平的相关性分析。GD患者治疗前血清IL-6,TNF-α水平显著高于对照组(P<0.01),131I治疗后IL-6,TNF-α水平明显降低。而IL-2治疗前显著降低,治疗后逐渐回升(P<0.01);血清IL-6、TNF-α水平与FT3、FT4呈明显正相关(P<0.05),而IL-2与FT3、FT4明显负相关。结论131I治疗Graves’病不仅可以安全有效地控制甲亢症状且可改善自身免疫紊乱,多种细胞因子的变化和131I治疗的效果有关。

Objective To study the changes of serum cytokine levels in patients with Graves disease（GD） before and after treated with iodine-131.Methods Using the method radoimmunoassay,the serum levels of interleukin-2（IL-2）,interleukin-6（IL-6） and TNF of Graves disease 45 patients before and after treated with iodine-131 and 30 control subjects were measured.Results The levels of IL-6,TNF-α of GD patients were significantly higher than that of the control group（P0.01）,the serum level of IL-2 of GD patients was significantly lower than that in the control subjects（P0.01）.The serum level of IL-6,TNF-α positively correlated with FT3,FT4（P0.05）,but IL-2 negatively correlated with FT3,FT4.Conclusions Cytokines play certain roles in the progressing of GD.Successful iodine 131 therapies would effectively suppress the immune status in Graves disease patients.