牛蒡子苷对糖尿病小鼠糖脂代谢的影响

Effect of Arctiin on Glucose and Lipid Metabolism in Diabetic Mice

目的:研究牛蒡子苷(ARC)对链脲佐菌素(STZ)所致糖尿病小鼠糖脂代谢的影响。方法:80只雄性昆明小鼠腹腔注射80 mg.kg-1链脲佐菌素(STZ)建立糖尿病小鼠模型,将造模成功的40只小鼠随机分为牛蒡子苷低剂量组(200mg.kg-1)、牛蒡子苷高剂量组(400 mg.kg-1)、模型组和二甲双胍(500 mg.kg-1)组各10只,同时设立正常对照组10只。各组灌胃(ig)给药,连续4周。给药结束后测定小鼠体质量、空腹血糖、糖化血清蛋白(GSP)、胰岛素(INS)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)。结果:与对照组比较,模型组小鼠TC、TG、LDL-C水平显著提高(P<0.05或P<0.01),HDL-C水平降低(P<0.01);牛蒡子苷高剂量组可显著降低糖尿病小鼠血清中TC、TG水平(P<0.05),对血清中HDL-C水平有升高趋势,但无显著性差异(P>0.05),对血清LDL-C水平无明显影响(P>0.05)。结论:牛蒡子苷能改善糖尿病小鼠糖脂代谢。

Objective： To study the effect of arctiin on glucose and lipid metabolism in the streptozotocin （STZ） - induced diabetic mice. Methods： 80 nmle Ktmming mice were intraperitoneally injected with 80 mg - kg-I STZ to establish diabetic model mice. 40 model mice were randomly divided into low （lose group of aretiin （200 mg · kg-1）, high dose group of arctiin （400 mg ·kg-1）, model group and metbine （500 mg · kg-1 ） group, with 10 rats in each group and normal control group with 10 mice was prepared. Each group was given lg administration for 4 consecutive weeks. The mouse body weight, fasting blood glucose, glyco- sytated serum protein （GSP）, insulin （INS）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL-C）, low density lipoprotein （LDL -C） were determined after the administration. Results： Compared witb those of the control group, TC, TG, LDL - C levels of model group increased significantly （ P 〈 0.05 or P 〈 0.01 ）, HDL - C level decreased （ P 〈 0.01 ） ; high dose arctiin could decrease TC, TG level in serum of diabetic mice （ P 〈0.05 ）, with the rise of serum in the HDL - C lev- el, hut no significant difference （P 〉 0.05 ）, no significant effect on serum LDL - C levels （P 〉 0.05）. Conclusion ： Arctiin can improve the glucose and lipid metabolism in diabetic mice.