应用Lenstar和IOLMaster测量眼球生物参数的比较研究

Comparison of the ocular biometric measurements between Lenstar and IOL Master

目的比较Lenstar与IOLMaster两种光学生物测量仪在测量眼球生物参数的一致性。方法选取2011年6月至2011年8月期间在我科参加广州双生子研究复查的家长作为研究对象。所有研究对象均完成Lenstar、IOLMaster、裂隙灯显微镜和眼底检查。取全部研究对象的右眼测量数据进行分析，对眼轴（AL）、前房深度（ACD）、角膜曲率半径（R）和白到白角膜直径（WTW）4个参数采用配对t检验比较其的测量差异，采用Pearson相关分析比较其相关性，并采用Bland—Ahman分析比较测量指标的一致性。结果共205人（205眼）完成了检查，男122人，女83人，平均年龄（44．3±5．0）岁。Lenstar和IOLMaster的AL、ACD、wTW、R1角膜最小屈光力子午线的曲率半径和R2角膜最大屈光力子午线的曲率半径测量值有差异。和IOLMaster相比，Lenstar的AL、R1和R2值较大，而ACD和WTW则较小，均有统计意义。两种测量方法的AL、R1和R2均呈高度线性相关关系（r〉0．9，P〈0．001），而ACD和WTW的相关性稍差。两种测量方法所测得的AL一致性最好，ACD和WTW一致性较差。结论对于不患有白内障的正常人群，Lenstar和IOLMaster测量的眼轴和角膜曲率半径参数有良好的相关性和一致性，在临床上可以相互替代，但对于测量前房深度和角膜直径参数其一致性差，在临床上不可以相互替代。

Objective To evaluate the agreement for ocular biological measurements obtained from Lenstar and IOL Master. Methods Patients who participated in our Guangzhou Twin Study follow-up exam- ination from June 2011 to August 2011 were enrolled. All subjects underwent the Lenstar LS 900, IOL Mas- ter, slit lamp and fundus examinations. The data of the right eye were analyzed. The differences in axial length （AL）, anterior chamber depth （AD）, radius （R） and white-to-white distance （WTW） between the two devices were analyzed with t-test. The correlation was analyzed with Pearson test, and the consistency was analyzed with Bland-Altman plot. Results 205 subjects （205 eyes） completed the examinations. A- mong them, 122 were male and 83 were female. The average age was （44.3± 5.0） years. There were sig- nificant differences in AL, ACD, WTW, R1 （minimum radius） and R2（maximum radius）. Lenstar results yielded significantly larger values of AL, R1 and R2, but smaller values of ACD and WTW than those from IOL Master. The linear correlation was very high for AL, R1 and R2 measurements （ r 〉 0. 9 ,P 〈 0. 001 ） , but the correlation was relatively weak for ACD and WTW measurements. The agreement was the highest in AL measurement, but the lowest in ACD and WTW measurements. Conclusion Lenstar and IOL Master produce similar measurements in AL and R for normal people with no catract, but the ACD and WTW meas- urements showed clinically significant differences.