替吉奥治疗老年胃癌患者的临床疗效

Clinical curative effect of S1 capsule for treatment of elderly patients with gastric cancer

目的探讨替吉奥治疗老年胃癌患者的疗效及不良反应。方法选取2008年7月至2012年5月收治的年龄≥60岁的老年胃癌患者126例,随机分为观察组(替吉奥治疗组,63例)和对照组(63例)。观察组患者采用替吉奥胶囊治疗,对照组采用奥沙利铂联合亚叶酸钙和氟尿嘧啶方案治疗。治疗结束后,对两组患者的有效率、不良反应和治疗满意度等分别进行统计分析。结果观察组患者的总有效率为88.9%,对照组患者的总有效率为71.4%,两组差异有统计学意义(P<0.05)。患者主要的不良反应为肝功能损伤、骨髓抑制和胃肠道反应,观察组患者出现III～IV级不良反应者8例(12.7%),对照组为15例(23.8%),两组差异有统计学意义(P<0.05)。对患者的治疗满意度统计显示,观察组患者的总满意度为61.9%,对照组为55.6%,两组差异无统计学意义(P>0.05)。结论替吉奥治疗老年胃癌患者疗效显著,不良反应较低,患者满意度较高。

Objective Through the use of S1 capsule to the treatment of elderly patients with gastric cancer,the curative effect and adverse reaction were observed.Methods From July 2008 to May 2012,126 elderly patients（age≥60 years）with gastric carcinoma in our hospital were selected and randomly divided into two groups,the observation group（63 cases）and control group（63 cases）.The patients of observation group with S1 capsule treatment,the patients of control group using oxaliplatin leucovorin and 5-fluorouracil regimen in treatment of.After the end of treatment,two groups of patients with treatment efficiency,adverse reaction,patient treatment satisfaction were analyzed.Results observation group patients with a total efficiency of 88.9%,compared to the control group in a total efficiency of 71.4%,there are statistical significance（P0.05）.The main adverse reactions in liver function injury,bone marrow suppression,gastrointestinal reactions in three aspects,observation group patients with III-IV toxicity and side effects of 8 cases（12.7%）,while the control group of 15 cases（23.8%）,there are statistical significance（P0.05）.Observation group patients with a total treatment satisfaction of 61.9%,and the control group was 55.6%,there is no statistical significance.Conclusions Application of S1 capsule to the treatment of elderly patients with gastric cancer curative effect remarkable,produce toxic side effect is low,patient satisfaction is high.