宫颈癌及癌前病变与生殖道感染的相关性分析

The relevance between reproductive tract infection and cervical carcinoma and precancerous lesions

目的探讨宫颈癌及癌前病变与生殖道感染的相关性及危险因素分析。方法对235例宫颈癌及癌前病变患者进行生殖道人乳头瘤病毒(HPV)、沙眼衣原体(CT)、单纯疱疹病毒Ⅱ型(HSV-2)和细菌性阴道病(EBV)检测,分析宫颈癌及癌前病变与生殖道病原体感染的关系。结果宫颈癌及癌前病变患者HPV、CT、HSV-2和EBV的感染率分别为97.2%、96.0%、63.4%和38.5%,与对照组比较,差异均有统计学意义(均P<0.01),两者高度相关。CT、HSV-2、EBV感染率也较高,分别为36.1%、30.6%和41.7%,与对照组比较,差异有统计学意义(均P<0.05),提示生殖道CT、HSV-2、EBV感染与宫颈癌、CIN的发生发展有一定的相关性。结论生殖道感染与宫颈癌及癌前病变有着密切的关系,需高度重视。

Objective To investigate the relevance between reproductive tract infection and cervical precancerous lesions and cervical cancer,and analyze the risk factors associated.Methods 235 patients with cervical precancerous lesions and cervical cancer were detected HPV,CT,HSV-2 and EBV.The relevance between reproductive tract infection and cervical l precancerous esions and cervical cancer were analyzed.Results HPV、CT、HSV-2 and EBV infection rate in patients with cervical precancerous lesions and cervical cancer was 97.2%,96.0%,63.4% and 38.5%,compared with the control group were significant differences（P0.01）.Both were highly related.CT、HSV-2 and EBV infection rate were also higher,36.1%,30.6% and 41.7% respectively,compared with controls there was significant difference（P 0.05）.It prompted that CT,HSV-2 and EBV infection were relate with the occurrence and development of cervical cancer,CIN.Conclusions Reproductive tract infection is closely related with cervical cancer and cervical precancerous lesions,and it is needed to attach great importance.