术前阴道放置米索前列醇对负压吸引术并发症的影响

Effect of pre-operational vaginal placement of misoprostol in reducing complications of vacuum aspiration

目的:阴道后穹隆放置米索前列醇,用作负压吸引术的宫颈准备,对孕早期的并发症风险降低有影响。方法:研究接受早期妊娠行负压吸引术的门诊患者400例,将其随机分组,米索前列醇组和安慰剂组各有200名。术前3 h给予400ng米索前列醇片或安慰剂。比较两组术前腹痛、恶心症状、阴道流血情况,术中是否需要机械宫颈扩张,手术时间,不全流产发生率。结果:两组人员经过术前、术中、术后2周的调查研究,米索前列醇组的平均术前宫颈扩张程度显著大于安慰剂组,负压吸引术平均所需时间、不全流产发生率则显著短于安慰剂组。结论:用负压吸引术行人工之前给予米索前列醇作为宫颈准备,有利于宫颈扩张和减少总体并发症的发生。

Objectives ： To investigate whether incidence of complications of trimester abortion by vacuum aspiration can be lowered by placing misoprostol on the rear of the vaginal vault. Methods ： Four hundred patients who received vacuum aspiration abortion in early pregnancy were randomly divided into two groups, 200 patients for each group. Three hours before the abortion operations, patients in the two groups were respectively given 400 ug misoprostol tablets and placebo drugs. The two groups are compared in terms of the symptoms of preoperative abdominal pain, nausea, vaginal bleeding, and the necessity of cervical dilatation, as well as the operation time and incomplete abortion incidence. Results： After 2 weeks＇ observation of the patients＇ preoperative, intraoperative and postoperative conditions, the results showed that the extent of average preoperative cervical dilatation of the misoprostol group was significantly greater than that of the placebo group, while the average time of vacuum aspiration and incomplete abortion incidence were significantly shorter than placebo group. Conclusion： Vaginal misoprostol placement can reduce the incidence of complications and increase cervical dilatation extent.