摘要
溃疡性结肠炎(Ulcerative colitis,UC)的发病被认为是宿主遗传易感性、黏膜免疫与肠道菌群共同作用的结果。许多临床研究显示,与正常人相比,UC患者存在不同程度的菌群失调。艰难梭菌、致病性大肠埃希菌等致病微生物被怀疑与UC的发病相关,但目前还未找到充分证据证明它们与UC患者肠道炎症间的因果关系。就UC患者肠道菌群分布的研究现状、肠道菌群检测方法及未来研究进展进行了阐述。
The onset of ulcerative colitis(UC) is considered to be a common interaction between the host genetic susceptibility,mucosal immunity and intestinal microflora.Many clinical researches show that UC sufferers have different degree of dysbacteriosis,compared with healthy persons.Clostridium difficile and pathogenic Escherichia coli were suspected to be responsible for the cause of UC.But there is no reliable evidence to prove the causality in between them.This review describes the current researches on intestinal flora distribution of UC sufferers,and methods for detection of intestinal bacteria and the related development.
出处
《微生物学免疫学进展》
2012年第6期68-72,共5页
Progress In Microbiology and Immunology
关键词
溃疡性结肠炎
炎症性肠病
肠道菌群
细菌培养
PCR
Ulcerative colitis
Inflammatory bowel disease
Intestinal flora
Bacterial culture
PCR
