适配小型动物及临床伽玛刀立体定向头架固定装置的研制

Development of the fixation device matching small animals and the clinical gamma knife stereotactic frame

目的为了满足小型动物伽玛刀放射外科实验研究的需要,设计和研发一种小型动物和临床伽玛刀立体定向头架的固定装置。方法该装置取材于高强度无磁性有机玻璃,由动物托盘、适配固定脚、耳和头齿固定等部件组成,以伽玛刀立体定向框架后组支杆作为固定。结果用Wistar大鼠验证了本适配装置的准确性。在X、Y、Z方向的平均误差分别为(0.15±0.27)、(0.27±0.33)、(0.26±0.42)mm。应用本装置对128只Wistar大鼠进行了伽玛刀照射,动物失固定率为3.7%,死亡率5.2%,其余动物均准确投照于目标点。结论该适配固定装置达到了设计要求,为伽玛刀放射外科的实验研究提供了便利条件。

Objective In order to meet the need of experimental study for gamma knife radiosurgery with small animals,the fixation device matching small animals and clinical gamma knife stereotactic frame was developed.Methods The high-strength non-magnetic organic glass was used as base material for the device,and posterior fixed poles from gamma knife stereotactic frame as the foundation of fixation.Its structure included animal tray,matching fixing feet and ear-head fixation device consisting of fixed-eat part and fixed-head part.Results In a test of accuracy with Wistar rats,errors in the X,Y,Z direction of（0.15±0.27）mm,（0.27±0.33）mm,（0.26±0.42）mm respectively were observed.Then 128 Wistar rats were radiated by gamma knife with the fixation device,and unfixed rate was 3.7% and mortality rate was 5.2%.Conclusion These results indicate that the fixation device meet design requirements,and provide convenience for the experimental study about gamma knife radiosurgery.