雷贝拉唑联合溃愈颗粒治疗Hp阳性十二指肠球部溃疡的临床疗效观察

Curative effect of rabeprazole combined with Kuiyu granule in treating Helicobacter Pylori-positive duodenal bulbar ulcer

目的探讨雷贝拉唑联合溃愈颗粒治疗Hp阳性十二指肠球部溃疡的临床疗效。方法选择120例Hp阳性十二指肠球部溃疡患者,随机分为治疗组和对照组,各60例。治疗组口服雷贝拉唑联合溃愈颗粒治疗,对照组口服雷贝拉唑治疗。观察治疗结束时临床症状和治疗结束4周后的Hp根除率、溃疡愈合率及随访半年和1年时的溃疡复发率及Hp再感染率。结果治疗结束时治疗组和对照组症状缓解有效率分别为100%和96.55%,差异无统计学意义(P>0.05),但是治疗组症状完全缓解天数(3.5±1.2)d少于对照组(8.1±2.5)d,差异具有统计学意义(P<0.05)。治疗结束4周后,治疗组和对照组Hp根除率分别为96.49%和91.38%;溃疡愈合率分别为98.25%和93.1%,差异无统计学意义(P>0.05)。治疗组和对照组随访半年Hp再感染率分别为5.56%和17.31%,溃疡复发率分别为3.7%和15.38%,差异均有统计学意义(P<0.05);随访1年Hp再感染率分别为11.76%和28%,溃疡复发率分别为7.84%和24%,差异均有统计学意义(P<0.05)。结论雷贝拉唑联合溃愈颗粒能够快速缓解十二指肠球部溃疡患者临床症状和减少其复发率。

Objective To investigate the curative effect of rabeprazole combined with Kuiyu granule on Hp-positive duodenal bulbar ulcer. Methods 120 cases with Hp-positive duodenal bulbar ulcers were randomly and equally divided into treatment group and control group. Rabeprazole combined with Kuiyu granule were used in the treatment group while rabeprazole was used in the control group. The clinical symptom, Hp eradication rate and ulcer healing rate after 4 weeks,and the ulcer relapse rate and Hp re- infection rate after 6 months or 1 year were bbserved. Results The total effective rate of the treatment group and the control were 100% and 96.55% ,respectively,with no significant difference （P〉0.05）. But compared with the control group,the days of com- plete remission of the treatment group was fewer （P〈0.05）. Four weeks after treatment,the Hp eradication rates in the treatment group and control group were 96.49G and 91.38% ,the ulcer healing rates were 98.25% and 93.1% ,respectively,and the differ- ence was not statistically significant （P〉0.05）. Follow-up half 6 months, the Hp re-infection rate were 5.56% and 17.31%, the ulcer relapse rate were 3.7 % and 15.38G, respectively, and the difference was statistically significant （P〈0.05）. Follow-up a year, the Hp re-infection rate were 11.76 % and 28 %, the ulcer relapse rate were 7.84% and 24%, respectively, and the difference was statistically significant （P〈0. 05）. Conclusion Rabeprazole combined with Kuiyu Granule can quickly relieve the clinical symptom of patients with duodenal bulbar ulcer and decrease the ulcer relapse rates.