宁波地区2例发热伴血小板减少综合征患者的临床特征

Clinical and epidemiological characteristics of 2 cases of thrombocytopenia syndrome accompanied by fever in Ningbo

目的分析宁波地区2例发热伴血小板减少综合征(SFTS)患者的临床特征及流行病学资料,以期加深对该病诊治的认识。方法回顾性分析2012年5月宁波地区首发的2例SFTS的临床资料,采用统一的诊断标准和流行病学个案调查表对病例进行调查。结果 1例危重型死亡,1例普通型治愈;临床表现起病急,持续高热,全身肌痛,浅表淋巴结肿大,白细胞及血小板进行性下降;2例患者均为居住在丘陵地区老年人,有田间或草丛活动史及蜱叮咬史,患者的密切接触者均无发病病例。结论 SFTS临床表现复杂,伴有多器官损害,其死因可能与休克、病毒心肌炎、呼吸衰竭等多脏器功能衰竭有关;患者均居住在丘陵地区,有田间或草丛活动史及蜱叮咬史。

Objective To understand the clinical and epidemiological characteristics of 2 cases of thrombocytopenia syndrome accompanied by fever in Ningbo and help the diagnosis and treatment of the disease. Methods The clinical and the epidemiological data were collected with standardized questionnaire from the first 2 cases occurred in Ningbo in May 2012 to conduct retrospective analysis. Results One case died duo to the severe illness and another one was cured. The clinical manifestations included acute onset, long time high fever, myalgia, enlarged superficial lymph nodes, progressive white cell and platelet reductions. The 2 cases were all old farmers who lived in wood and hilly areas, had histories of working in the fields or in the underbrush, and had histories of tick-bite. There were no secondary cases among the close contacts. Conclusion The clinical manifestations of thrombocytopenia syndrome accompanied by fever are complex, including multiple organ damage. The death may be related with shock, viral myocarditis, respiratory failure and multiple organ failure. The patients are usually the people who live in wood and hilly area, have histories of working in fields or in underbrush and have histories of tick-bite.