口服碘油胶丸的哺乳期妇女和婴幼儿碘代谢研究

Research on influence of taking oral iodized oil capsule on iodine metabolism in lactating women and their infants

目的研究补充一剂碘的哺乳期妇女母乳-乳汁-婴儿的碘代谢过程。方法在阿克苏地区库车县牙哈镇4个村选择109名近半年内未服用过碘油丸的19～36岁哺乳期妇女及20日龄至18月龄婴幼儿,服药后的第1、3、7、14、30、50、75、100天分别采集实验组及对照组的哺乳妇女尿碘、乳汁及婴幼儿尿样,进行碘含量测定。结果哺乳期妇女尿碘及乳汁碘与婴幼儿尿碘之间呈正相关。经统计学检验,婴幼儿尿碘与哺乳期妇女尿碘呈正相关,相关系数(r)=0.773,P<0.001;对照组哺乳期妇女尿碘与婴幼儿尿碘之间r=0.526,P<0.001;婴幼儿尿碘与哺乳期妇女乳汁碘呈正相关,r=0.389,P<0.001;对照组哺乳期妇女乳汁碘与婴幼儿尿碘之间r=0.307,P<0.001。结论婴幼儿的碘来源主要是乳汁,哺乳妇女的碘营养状况直接影响婴幼儿。库车牙哈镇哺乳期妇女通过口服200 mg碘油胶丸可对婴幼儿尿碘最长保护期为100 d,乳母口服200 mg碘油胶丸对库车牙哈镇哺乳期妇女尿碘最长有效保护期不到50 d;可通过乳汁分泌到婴幼儿的最长保护期为100 d。

Objective To understand the influence of taking oral iodized oil capsule on iodine metabolism of lactating women and their infants. Methods A total of 109 lactating women （aged 19 -36 years） and their children （aged 20 days-18-months） taking no oral iodized oil capsules within half a year were selected from 4 villages of Yaha township of Kuche county, Aksu to carry out on-site intervention. To detect iodine concentrations in urine and milk, the urine samples were taken from the lactating women and their infants respectively and milk samples were taken from the lactating women at 1, 3, 7, 14, 30, 50, 75 and 100 days. The same samples were also taken from control groups. Results Positive correlations between the urine and milk iodine concentrations of the lactating women and the urinary iodine concentration of the infants was found after statistical analysis （ r = 0. 773, P 〈 0. 001, r = 0. 526, P 〈 0. 001 respectively） The relevant indicators in control groups were r = 0. 389, P 〈 0. 001 and r = 0. 307,P 〈 0. 001. Conclusion It is suggested to increase the dosage or time of oral iodized oil capsule administration due to its short time protection, but whether to shorten this iodine supplement interval in severe iodine deficient area needs further study.