血清胱抑素C及尿微量清蛋白检测在早期糖尿病肾病诊断中的应用价值

Application value of serum CysC and urine mAlb in diagnosing early diabetic nephropathy

目的分析血清胱抑素C（CysC）及尿微量清蛋白（mAlb）联合检测在诊断早期糖尿病肾病（DN）中的应用价值。方法将确诊的尿mAlb排泄率为20~200 mg的78例早期DN患者分为DN组,无肾病糖尿病（NDN）患者52例分为非DN（NDN）组,同时将62例门诊健康体检者作为对照组。测定三组受检者血清肌酐（Cr）、尿素氮（BUN）和CysC水平,同时测定三组受检者晨尿中mAlb并进行比较。结果早期DN患者中出现肾损害,血清中各检测指标检出率由高至低依次为CysC＋mAlb、CysC、mAlb、Cr、BUN,DN组患者血清CysC和尿mAlb均显著高于对照组和NDN组（P〈0.05）。结论 DN组患者血清CysC及晨尿mAlb水平升高与糖尿病早期肾损害密切相关,二项指标联合检测有助于临床诊断早期DN。

Objective To analyze the application value of combined detection of serum CysC and urine mAlb for diagnosing early diabetic nephropathy（DN）.Methods 130 patients with early DN and urine mAlb 20-200 mg were devidied into the DN group（78 cases）and the non-DN（NDN）group（52 cases）.Contemporaneous 62 subjects with healthy examination in the outpatient department were selected as the control group.Serum Cr,BUN and CysC and morning urine mAlb were detected and compared among 3 groups.Results Renal damage apeared in early DN.The detection rates of various serum indexes in early DN from high to low in turn were CysC＋ mAlb,CysC,mAlb,CR and BUN.Serum CysC and urine mAlb in the DN group were significantly higher than those in the NDN group and control group（P0.05）.Conclusion Increrase of serum CysC and morning urine mAlb in the DN patients is closely related with early DN.Combination detection of these two indexes will help to diagnose early DN.