毛酸浆宿萼的化学成分研究(Ⅰ)

Chemical constituents in persistent calyx of Physalis pubescens (Ⅰ)

目的研究毛酸浆Physalis pubescens干燥宿萼的化学成分。方法利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压柱色谱及半制备高效液相色谱等方法分离纯化,通过核磁共振谱、质谱等光谱数据鉴定化合物结构。结果分离得到9个化合物,分别鉴定为3,6,11-三甲基-3-羟基-1,6(E),10-十二碳三烯-8-O-β-D-葡萄糖苷(1)、3′,5-二羟基-3,7,4′-三甲氧基黄酮(2)、山柰酚-3-O-β-D-槐糖苷(3)、山柰酚-3-O-α-L-鼠李糖-(1→6)-β-D-葡萄糖苷(4)、山柰酚-3-O-β-D-葡萄糖-7-O-α-L-鼠李糖苷(5)、3-羟基-4-甲氧基苯甲酸(6)、银杏内酯A(7)、银杏内酯B(8)、3,7,4′-三甲氧基杨梅黄酮(9)。结论化合物1为新化合物,命名为毛酸浆苷A,化合物2～8为首次从该属植物中分离得到。

Objective To investigate the chemical constituents in the dried persistent calyx of Physalis pubescens. Methods The constituents were isolated by chromatography on silica gel, Sephadex LH-20, and medium pressure columns, and semi-preparative liquid chromatography, then their structures were elucidated by chemical properties and spectroscopic analyses. Results Nine compounds were isolated and their structures were identified to be 3, 6, 11-trimethyl-3-hydroxyl-1, 6（E）, 10-dodecatriene-8-O-β- D-glucoside （1）, 3＇, 5-dihydroxy-3, 7, 4＇-trimethoxyl flavone （2）, kaempferol-3-O-β-D-sophoroside （3）, kaempferol-3-O-α-L- rhamnosterin-（1→6）-β-D-glucoside （4）, kaempferol-3-O-β-D-glucoside-7-O-α-L-rhamnosterin （5）, 3-hydroxyl-4-methoxy benzoic acid （6）, ginkgolide A （7）, ginkgolide B （8）, and 3, 7, 4＇-trimethyl-myricetin （9）. Conclusion Compound 1 is a new compound named physaliside A and compounds 2--8 are obtained from the plants in genus Physalis L. for the first time.