鼻咽癌相关固有免疫分子及其潜在临床转化前景

Nasopharyngeal carcinoma related innate immune molecules andtheir potential value in translational medicine

鼻咽癌是我国南方常见恶性肿瘤,目前其早期诊断仍面临巨大的困难。本课题组运用基因组学、转录组学、蛋白质组学和组织微阵列等高通量技术大规模筛选鼻咽癌分子标记物,发现在鼻咽上皮分泌的两类重要的固有免疫分子——腭、肺及鼻咽上皮克隆蛋白家族和乳转铁蛋白,不仅是构成机体天然防御系统的重要组成部分,还通过特定的信号转导通路引起一系列的生物学效应,影响鼻咽癌的发生、发展进程,有望应用于鼻咽癌的早期诊断、个体化治疗及临床预后。

Nasopharyngeal carcinoma （NPC） is a common epithelial malignancy in Southern China, yet there are some difficulties in its early diagnosis. When using a series of large-scale screening techniques from genomics, transcriptomics, proteomics and tissue microarray to find NPC- related early biomarkers, we identified two kinds of innate immune proteins, palate,lung and nasal epithelial clone （PLUNC） family protein and lactotransferrin （LTF）, which were significantly down-expressed in abnormal tissue. These molecules on one hand constitute the important part of the natural barrier system to protect the nasopharyngeal epithelium from pathogenic microorganism, on the other hand could trigger a series of signaling pathway and affect the process of NPC, showing their potential role in the early diagnosis, individualized treatment and clinical prognosis of NPC.