Hedgehog信号通路的研究进展

Research progress of Hedgehog signaling pathway

Hedgehog(Hh)蛋白可以调节后生胚胎以及成体结构,Hh信号通路失调可以导致多种疾病的发生。现有的Hh信号通路包括以调节Gli家族蛋白为主的所谓的经典途径,但是也有最近的一些研究提示Hh信号存在着非依赖Gli蛋白家族的所谓的非经典途径。本文探讨Hh可能的信号通路。

Hedgehog （Hh） proteins can regulate the development of metazoan embryonic and adult structures. Any disorder of Hh signaling pathways results in various human diseases. Now Hh signaling pathway has focused on the mehanism by which Hh regulates the Gli family of transcription factors, the so-called ＂canonical＂ Hh signaling pathway. But many studies have shown that Hh proteins can also signal through Gli-independent mechanisms called ＂non- canonical＂ signaling pathways. This paper will discuss the possible Hh signaling pathways.