庆大霉素联合腰大池持续引流治疗颅内感染30例临床观察

Clinical observation on gentamycin combined with lumbar cistern constant drainage in treating intracranial infection in 30 cases

目的观察庆大霉素联合腰大池持续引流治疗颅内感染的临床疗效。方法将60例颅内感染患者随机分为观察组、对照组各30例。两组均在积极对症治疗的同时给予腰大池持续引流,观察组同时给予庆大霉素2mg加0.9%氯化钠溶液5mL髓鞘注射。结果观察组痊愈率为36.67%,对照组为20.00%,两组相比差异有统计学意义(P<0.05)。观察组总有效率为76.67%,对照组为66.67%,两组相比差异有统计学意义(P<0.05)。结论庆大霉素联合腰大池持续引流治疗治疗颅内感染,疗效确切,不良反应小,显著提高了治愈率。

Objective To observe the clinical effects of gentamycin combined with lumbar cistern constant drainage in the treatment of intracranial infection. Methods Sixty patients with intracranial infection were randomly divided into the observation group and control group, 30 cases in each group. Both groups were administered with symptomatic treatment and lumbar cistern constant drainage while the patients in the Observation group were also injected with 2 mg of gentamycin and 5 mL of physiological saline to the myelin sheath. Results The cure rate of the observation group was 36.67%, higher than 20.00% of the control group with significant difference （P 〈 0.05）, Total effective rate of the observation group was 76.67%, superior to 66.67% of the control group with significant difference （P 〈 0.05）. Conclusion Gentamycin combined with lumbar cistern constant drainage show definite efficacy in treating intracranial infection and raise the cure rate notably with minor adverse reaction.