艾司西酞普兰片联合氯硝西泮注射液治疗焦虑症的临床研究

Clinical research of Escitalopram Tablets combined with Clonazepam Injection in the treatment of anxiety disorders

目的观察艾司西酞普兰片联合小剂量氯硝西泮注射液治疗焦虑症的疗效和不良反应。方法对65例符合标准的焦虑症患者分成两组,研究组33例给予艾司西酞普兰片联合氯硝西泮注射液静脉滴注,对照组32例仅用艾司西酞普兰片治疗,疗程为6周,采用汉密尔顿焦虑量表(HAMA)和不良反应量表(TESS)评定疗效和不良反应。结果两组总体疗效差异有统计学意义,氯硝西泮注射液组(研究组)抗焦虑显效更快;在第6周末,治愈率、临床显效率明显高于对照组;在整个治疗过程中,副反应没有明显增加。结论艾司西酞普兰片短期合并氯硝西泮注射液可以加快焦虑综合征缓解的速度,明显提高焦虑症的治疗效果,副反应没有明显增加,值得临床推广。

Objective To observe the curative effects and adverse reactions of Escitalopram Tablets combined with small dose of Clonazepam Injection in treatment of anxiety disorders. Methods Sixty-five patients met the criteria of anxiety disorders were randomly divided into research group and control group. In research group, 33 patients were given Escitalopram Tablets with Clonazepam Injection, while in control group, only Escitalopram Tablets were provid- ed. The curative effects and adverse reactions were evaluated by HAMA scale and TESS scale after 6 weeks treatment in both groups. Results There was significant difference in total curative effect. To be specific, effect of anti-anxiety in research group was faster than that in control group. At the end of sixth week, the cure rate and clinical effective rate were remarkably higher than those in control group. Throughout the treatment, the side reactions did not show great increase. Conclusion The Escitalopram Tablets combined with Clonazepam Injection in short-term can speed up the alleviation of anxiety disorders, significantly improve its curative effect, and there is no obvious increase in side reac- tions, it is worthy of clinical extension.