艾司西酞普兰对广泛性焦虑患者的疗效观察

The clinical observation of escitalopram on patients with generalized anxiety disorder

目的观察艾司西酞普兰对广泛性焦虑患者疗效及不良反应的影响。方法将100例广泛性焦虑患者随机分为实验组与对照组,每组50例。实验组予艾司西酞普兰片口服15mg/d,对照组予艾司西酞普兰模拟剂15mg/d,两组进行6周的治疗,采用汉密尔顿焦虑量表(HAMA)评价疗效,抗抑郁药副反应评定量表(SERS)评定艾司西酞普兰的不良反应。结果与对照组比较,治疗后实验组HAMA评分明显下降(P<0.01);实验组治疗的总有效率为70%(35例),对照组为30%(15例),两组比较差异有统计学意义(P<0.01)。结论艾司西酞普兰对广泛性焦虑患者的疗效显著,安全性高。

Objective To observe the efficacy and adverse reactions of escitalopram on patients with generalized anxi- ety disorder. Methods One hundred patients with generalized anxiety were randomly divided into two groups, the ex- perimental group and the control group, and each group had 50 cases. The experimental group received escitalopram tablet 15 mg/d, the control group received escitalopram simulation agent 15 rag/d, and two groups were treated for 6 weeks. The efficacy was assessed by using Hamilton Anxiety Scale （HAMA） and the escitalopram adverse reaction was assessed by using antidepressant Side Effects Rating Scale （SERS）. Results Compared with the control group, the ex- perimental group% HAMA score decreased significantly after treatment （P 〈 0.01）; The total effective rate of the exper- imental group was 70% （35 cases）, and that of the control group was 30% （15 cases）, and there was significant differ- ence between the two groups （P 〈 0.01）. Conclusion Escitalopram on patients with generalized anxiety disorder has obvious curative effect and high safety.