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小儿止咳平喘露的平喘作用及其对外周血可溶性细胞黏附分子-1的影响

Changes of serum soluble intercellular adhesion molecule-1 in children patients with bronchial asthma by Pediatric Cough and Asthma Relieving Gel
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摘要 目的探讨小儿止咳平喘露的平喘作用及其对外周血可溶性细胞黏附分子-1的影响。方法选取本院2010年10月~2012年3月收治的咳喘患儿236例,随机分为两组,采用小儿止咳糖浆治疗患儿118例为对照组,采用小儿止咳平喘露治疗患儿118例为观察组,分别进行组胺引喘法观察、枸橼酸引咳法观察、痰液嗜酸性粒细胞计数、外周血可溶性细胞黏附分子-1检测,比较两组患儿的各项临床指标。结果观察组组胺引喘潜伏期[(81.4±16.5)s]明显长于对照组[(52.7±12.0)s],观察组枸橼酸引咳潜伏期[(48.3±12.6)s]明显长于对照组[(30.1±9.2)s],观察组痰液嗜酸性粒细胞计数[(1.3±0.6)×106个/mL]明显低于对照组[(2.1±1.0)×106个/mL],观察组外周血可溶性细胞黏附分子-1[(42.7±13.8)μg/L]明显低于对照组[(59.2±17.5)μg/L],差异均有统计学意义(P<0.05)。结论小儿止咳平喘露具有显著的止咳平喘功效,不仅能明显减少患儿痰液中的嗜酸性粒细胞,还能有效降低患儿外周血可溶性细胞黏附分子-1的水平。 Objective To investigate the antiasthmatic effect of Pediatric Cough and Asthma Relieving Gel and its ef- fect on peripheral blood soluble cell adhesion molecule-1. Methods 236 children with cough and asthma were select- ed in the hospital from October 2010 to March 2012, who were divided into two groups randomly. 118 children used cough syrup in the treatment as the control group. 118 children used Pediatric Cough and Asthma Relieving Gel in the treatment as the observation group. All children underwent observation of cough induced by histamine, observation of cough induced by citric, acid, sputum eosinophil cells countl detection of peripheral blood soluble cell adhesion molecule-1. Clinical indexes were compared between two groups. Results Cough latency induced by histamine in the observation group [(81.4±16.5)s] was significantly longer than that in the control group [(52.7±12.0)s]. Cough latency induced by citric acid in the observation group [(48.3±12.6)s] was significantly longer than that in the control group [(30.1±9.2)s]. Sputum eosinophil cells count in the observation group [(1.3±0.6)×10^6/mL] was significantly lower than that in the control group [(2.1 ±1.0)×10^6/mL]. Peripheral blood soluble cell adhesion molecule-1 in the observation group [(42.7±13.8)μg/L] was significantly lower than that in the control group [(59.2±17.5)μg/L]. The difference was statistically significant (P 〈 0.05). Conclusion Pediatric Cough and Asthma Relieving Gel can obvious relieve cough and asthma, which not only can reduce the induced sputum in children with eosinophilic, but also can effectively re- duce level of peripheral blood soluble cell adhesion molecule-1 of children.
作者 宋慧珠
出处 《中国医药导报》 CAS 2013年第5期51-52,55,共3页 China Medical Herald
关键词 儿止咳平喘露 小儿止咳糖浆 平喘作用 外周血可溶性细胞黏附分子-1 Pediatric Cough and Asthma Relieving Gel Cough syrup for children Asthma Peripheral blood solublecell adhesion molecule-1
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