韶关市1190例手足口病病原体检测结果分析

Analysis and pathogenic diagnosis of 1190 hand-foot-mouth disease in Shaoguan

目的分析韶关地区手足口病病原体分布情况。方法收集2011年1月～12月的1190例手足口病患者的咽拭子,采用实时荧光PCR方法检测肠道病毒71型(EV71)和柯萨奇病毒A组16型(CoxA16)。结果在1190份标本中病毒核酸阳性率为11.51%(137/1190),其中EV71占60.58%(83/137),CoxA16占39.42%(54/137);6月份高发,占29.08%(346/1190);男女比例为1.64:1,且0～4岁的患儿占93.11%。结论韶关地区2011年手足口病病原体以EV71为主,6月份高发,主要分布在0～4岁,男性多于女性,实时荧光PCR可用于手足口病病原体的检测,对手足口病的诊疗和防控具有重要意义。

Objective To analyze the pathogenic diagnosis of the hand-foot-mouth disease （HFMD） in the city of Shaoguan. Methods Throat swab of 1190 HFMD patients were collected from January to December in 2011. Real-time PCR was used to detect enterovirus71 （EV71） and CoxsackievirusAl6 （CoxA 16）. Results The positive rate of the virus nucleic acid was 11.51%（137/1190）, EV71 was 60.58%（83/137） , CoxA16 was 39.42%（54/137）. The peak of HFMD infection ratio was 29.08% （346/1190） in June. Male to female ratio was 1.64：1, 0-4 years old children accounted for 93.11%. Conclusions HFMD was mainly caused by EV7I in Shaoguan 2011. The peak of HFMD was in June and mainly distributed in 0-4 years old children. Male more than female. Real-time PCR can be used to pathogenic diagnosis of HFMD, which plays an important role in diagnosis, treatment, prevention and control of HFMD.