慢性乙型肝炎患者血清胱抑素C浓度与肝功能指标的相关性

The correlation between serum cystatin C concentration and liver function indexes in patients with chronic hepatitis B.

目的研究慢性乙型肝炎患者血清胱抑素C(CysC)水平与肝功能指标间的关系。方法回顾性分析221例慢性乙型肝炎患者的血清CysC水平与ALT、AST、Alb、Glo、TBIL、Cr、BUN等指标之间的关系。并以CysC为因变量,以年龄、ALT、AST、Alb、Glo、TBIL和Cr为自变量进行多元回归分析。结果总体CysC水平为(1.05±0.40)mg/L,其中男性高于女性(P<0.05);年龄与CysC水平呈正相关(r=0.069,P<0.05);HBeAg阳性者CysC水平低于阴性者,HBeAb阴性者低于阳性者(P<0.05)。CysC水平与ALT、AST、Alb、Glo和TBIL水平的相关系数分别为-0.171、-0.139、-0.286、0.320和0.181(P<0.05)。多元回归分析显示Cr、Glo、Alb和年龄依次进入回归方程(r=0.620,P<0.05)。结论慢性乙型肝炎CysC水平受肝功能影响,但主要影响因素仍是肾功能相关指标。

Objective To study the correlation between serum cystatin C （CysC） and liver function parameters in patients with chronic hepatitis B （CHB）. Methods Retrospective study was carried out on 221 cases of CHB. The cor- relations between serum CysC and ALT, AST, Alb, Glo, TBIL, Cr, and BUN were analyzed with multiple regression a- nalysis. Results The mean CysC level was （ 1.05 ±0. 40） mg/L. The CysC level in males was significantly higher than that in females （P 〈 0. 05 ）. The CysC was significantly positive correlated with age （ r = 0. 069, P 〈 0. 05 ）. The CysC level was significantly lower in HBeAg（ ＋ ） or HBeAb（ - ） patients （P 〈0. 05）. The correlation coefficient between Cy- sC and ALT, AST, ALB, Glo or TBIL was - 0. 171, - 0. 139, - 0. 286, 0. 320 or 0. 181, respectively （P 〈 0.05）. Mul- tivariate analysis showed that Cr, Glo, Alb and age contributed to the regression equation （r = 0. 620, P 〈 0. 05）. Con- clusion The CysC is influenced by liver function in CHB patients, though the main impact factors are still renal function.