氟比洛芬酯超前镇痛对上腹部术后患者T细胞免疫功能的影响

Effects of flurbiprofen axetil preemptive analgesia on T cell immune functions in postoperative patients with upper abdominal

目的探讨氟比洛芬酯超前镇痛对上腹部术后患者T细胞免疫功能的影响。方法将76例上腹部手术患者按随机数字表法分为观察组（40例，患者切皮前10min静脉注射氟比洛芬酯100mg）和对照组（36例，患者切皮前10min静脉注射0．9％氯化钠10m1）。分别于术前1d及术后2、48h抽血，应用流式细胞术检测患者的CD4＋、CD8^＋、自然杀伤细胞（NK细胞）以及CDg／CD8^＋。结果两组术后2hCD8^＋以及NK细胞均明显低于术前（观察组：0．1850±0．0550比0．2430±0．0856、0．1197±O．0673比0．1598±0．0775，对照组：0．1219±0．0571比0．2385±0．0847、0．0778．±0．0311比0．1621±0．0806，P〈0．05），但观察组明显高于对照组（P〈0．05）。术后48h，两组CD4＋、CD8^＋以及NK细胞与术前比较差异无统计学意义（P〉0．05）。结论上腹部手术患者术后存在T细胞免疫功能紊乱，氟比洛芬酯超前镇痛可以改善患者术后T细胞免疫功能。

Objective To study the effects of flurbiprofen axetil preemptive analgesia on T cell immune functions in postoperative patients with upper abdominal. Methods Seventy-six patients with upper abdominal operation were divided into observation group （40 cases ） and control group （36 cases ） by random digits table, observation group and control group were given intravenous injection of 100 mg flurbiprofen axetil or 10 ml 0.9% sodium chloride 10 rain before skin incision respectively. Peripheral venous blood samples were collected for the determination of CD4^＋,CD8^＋,natural killer cell （NK cell） and CD4＋/CD8^＋ by flow cytometry 1 day preoperative, 2 and 48 h postoperative. Results In two groups, the CD8^＋ and NK cell of 2 h postoperative were lower significantly than those of preoperative （observation group：0.1850 ± 0.0550 vs.0.2430±0.0856,0.1197 ±0.0673 vs. 0.1598 ±0.0775;control group：0.1219 ±0.0571 vs. 0.2385 ± 0.0847,0.0778 ± 0.0311 vs. 0.1621 ± 0.0806, P 〈 0.05 ）, however, the observation group was significantly higher than the control group （P 〈 0.05 ）. There was no significant difference in CDg, CD8^＋ and NK cell of 48 h postoperative between two groups. Concision There are disorders on the T cell immune functions in postoperative patients with upper abdominal, but flurbiprofen axetil preemptive analgesia can improve the T eell immune function.