新辅助化疗对局部晚期宫颈癌组织微血管密度和微淋巴管密度的影响

The effects of neoadjuvant chemotherapy on microvessel density and lymphatic microvessel density in locally advanced uterine cervical cancer

目的探讨新辅助化疗对局部晚期宫颈癌组织微血管密度（MVD）和微淋巴管密度（LMVD）的影响。方法选择50例行新辅助化疗患者的宫颈癌组织及20例正常宫颈组织，采用免疫组织化学方法测定MVD和LMVD，分析新辅助化疗对其的影响。结果新辅助化疗前宫颈癌组织MVD、LMVD分别为（29．21±3．69）％、（24．15±4．12）％，均明显高于正常宫颈组织的（9．11±2．81）％、（5．59-1-1．08）％，差异有统计学意义（P〈0．05）；新辅助化疗后宫颈癌组织MVD、LMVD分别为（21．14±2．11）％、（17．24±2．21）％，均较新辅助化疗前明显降低，差异有统计学意义（P〈0．05）。术后生存时间多血管组（MVD〉21％，20例）、多淋巴管组（LMvD〉17％，23例）分别为（22．10±6．25）、（20．10±4．12）个月，明显低于少血管组（MVD≤21％，29例）和少淋巴管组（MVD≤17％，26例）的（33．45±8．11）、（30．16±5．77）个月（P〈O．05）。MVD和LMVD与患者术后生存时间呈负相关（r=-0．216，P=0．001；r=-0．126，P=0．009）。结论新辅助化疗能有效降低局部晚期宫颈癌组织MVD和LMVD，对于改善宫颈癌患者的近期疗效和远期生存有一定的作用。

Objective To investigate the effects of neoadjuvant chemotherapy （NACT） on microvessel desity （MVD） and lymphatic microvessel density （LMVD） in locally advanced uterine cervical cancer （UCC）. Methods Fifty specimens of UCC tissues who received NACT and twenty specimens of normal uterine cervical tissues were collected. The MVD and LMVD were examined by immunohistochemistry, and the clinical impact of NACT was analyzed. Results The MVD and LMVD in UCC tissues before NACT [（29.21 ± 3.69）% and （24.15 ±4.12）% ] were significantly higher than those in normal cervical tissues [ （9.11 ± 2.81 ）% and （5.59 ± 1.08 ）% ] （P 〈 0.05 ）. The MVD and LMVD were significantly decreased after NACT [ （21.14 ± 2.11 ）% and （ 17.24 ± 2.21 ）% ] than before NACT（P 〈 0.05 ）. The postoperative survival time in multiple vessels group （MVD 〉 21% ,20 cases） and lymph vessels group （LMVD 〉 17% ,23 cases） were significantly shorter than that in less vessels group （MVD ≤21% ,29 cases ） and lymph vessels group （LMVD ≤17% ,26 cases ） [ （22.10 ± 6.25 ） mouths vs. （33.45 ± 8.11 ） months, （20.10 ±4.12） months vs. （30.16 ＋5.77） months,P 〈0.05]. There was a negative correlation between the MVD and LMVD and postoperative survival times （r =-0.216,P = 0.001 ;r =-0.126,P = 0.009 ）. Conclusion NACT can be helpful to reduce the MVD and LMVD,and has some effect on improving short-term treatment effect and long-term survivals.