宫颈癌同步放化疗骨髓抑制的相关因素分析

Correlation factors of bone marrow suppression in concurrent chemoradiotherapy for cervical cancer

目的:探讨宫颈癌同步放化疗患者在治疗过程中出现骨髓抑制的高危因素。方法:回顾性分析99例同步行放化疗的宫颈癌患者资料,分别对年龄、是否合并内科疾患、肿瘤临床分期、分型、放化疗方案、化疗疗程、同步放化疗持续时间以及同步放化疗前双侧子宫动脉灌注化疗疗程与骨髓抑制的发生进行相关性分析。结果:骨髓抑制的发生与患者年龄、是否合并内科疾患、肿瘤临床分期、分型、化疗疗程以及同步放化疗前双侧子宫动脉灌注化疗疗程无相关性(P>0.05);与放化疗方案以及同步放化疗持续时间相关(P<0.05)。结论:放化疗方案和同步放化疗持续时间是宫颈癌同步放化疗患者治疗期间发生骨髓抑制的高危因素。

Objective： To study risk taetors assoeiated with bone marrow suppression during treatment of concurrent ehemoradiolherapy tor cervical cancer. Methods： The data were analyzed in 99 eases of concurrent ehemoradiotherapy for eervieal cancer. The age, a merger of the medical eonditions,elinieal stage and type of tumor, radiotherapy and chemotherapy programs, cycles of ehemotherapy,duration of concurrent ehemora（liotherapy, cyctes of intraulerine arterial infusion chemotherapy before concurrent ehemnra（liotherapy with bone marrow suppression were analyzed respeetlvely. Results： Age, a merger of the nledieal （onditions, clinical stage and type of tumor. cycles of ehemotherapy and intra-uterine arterial inihsion chemotherapy before enneurrent ehenmradiotherapy were uneoneerned with bone marrow suppression （P〉0.05）. Radiotherapy and chemotherapy programs and duration of concurrent ehemoradiotherapy had relationship with bone marrow suppression（P〈0.05）. Conclusion： Radiotherapy and chemotherapy programs and duration of eoueurrent ehemnradintherapy are risk factors associated with bone marrow suppression during treatment of concurrent chemnradiotherapy for cervical eaneer.