摘要
目的评价血浆1,3-β-D-葡聚糖检测(G试验)对恶性血液病患者侵袭性真菌感染(IFD)的诊断价值。方法对220例血液恶性肿瘤患者进行回顾性分析。以中国IFD工作组制定的《血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准与治疗原则》为对照标准,研究血浆1,3-β-D-葡聚糖浓度单个指标在诊断IFD时受试者工作特征(ROC)曲线下面积、敏感性、特异性和诊断所需时间。结果相比于金标准,血浆1,3-β-D-葡聚糖浓度单个指标诊断恶性血液病患者IFD的ROC曲线下面积、敏感性、特异性和诊断所需时间分别为0.946 1、98.6%、83.0%和(3.86±2.92)d。结论 G试验诊断恶性血液病患者IFD较传统诊断方法在敏感性及所需时间上均有较大优势,且有较好的阴性预测值,能帮助早期诊断和排除IFD,提高临床诊治效果,减轻患者医疗负担。
Objective To evaluate the significance of plasma 1,3-beta-D-glucan assay（ G test）for the diagnosis of invasive fungal diseases （IFD） in patients with malignant hematological diseases. Methods A retrospective analysis was performed in 220 inpatients with malignant hematological tumor. According to Diagnostic Criteria and Principles of Treatment of Invasive Fungal Infections in Patients with Blood Diseases^Malignancies as gold standard, the plasma 1,3- beta-D-glucan concentration＇s area under the receiver operating characteristic （ROC） curve, sensitivity, specificity and time to diagnosis in the diagnosis of IFD were analyzed. Results Comparing the gold standard, the plasma 1, 3-beta- D-glucan coneentration＇s area under the ROC curve, sensitivity, specificity and time to diagnosis were 0. 946 1, 98.6%, 83.0% and （ 3.86 ± 2.92） d, respectively. Conclusions G test has good sensitivity and time to diagnosis for the diagnosis of IFD in patients with malignant hematological diseases, and has a good negative predictive value in early diagnosis and exclusion of IFD. It can improve the efficiency and reduce the care burden of patient.
出处
《检验医学》
CAS
2013年第1期7-10,共4页
Laboratory Medicine
