辛伐他汀联合氨氯地平治疗对血压变异性的影响分析

The impact analysis of simvastatin combined with amlodipine on blood pressure variability

目的:观察辛伐他汀联合氨氯地平对高血压患者血压变异性的影响。方法:100例原发性高血压患者随机分为治疗组和对照组(各50例),两组均给予氨氯地平2.5mg/d治疗,治疗组在此基础上加用辛伐他汀20mg/d。治疗12周后,比较两组治疗前后血脂变化,并进行24h动态血压监测,比较两组治疗前后血压平均值、血压变异性的变化。结果:治疗组12周后较治疗前相比,血总胆固醇、三酰甘油、低密度脂蛋白明显降低,高密度脂蛋白升高;治疗组12周后与治疗前比较,动态血压平均值、血压变异性均显著下降,24h平均收缩压、白昼平均收缩压、夜间平均收缩压、24h收缩压变异性、白昼收缩压变异性、白昼舒张压变异性、夜间收缩压变异性较对照组降低。结论:辛伐他汀联合氨氯地平可有效降压,调节血脂,并可显著改善原发性高血压患者的血压变异性。

Objective：To observe the effect of simvastatin combined with amlodipine on hypertension patientsp blood pressure variability. Methods ..One hundred cases with primary hypertension were randomly divided into treat- ment group and control group,all 50 cases,two group were treated by 2.5 mg/d amlodipine antihypertensive treat- ment,the treatment group was based on combined with simvastatin 20 mg/d. After 12 weeks of treatment,were com- pared between the 2 groups before and after treatment the changes of blood lipids,and using 24 h ambulatory blood pressure monitoring,were compared between the 2 groups before and after treatment,blood pressure mean values of blood pressure variability. Results .. The treatment group after 12 weeks more than before,serum total cholesterol, trigiyceride,low density lipoprotein was significantly reduced, high density lipoprotein elevation ; the treatment group after 12 weeks compared to ambulatory blood pressure mean values,blood pressure variability were significantly de- creased, 24 h average systolic blood pressure,the mean systolic ,mean systolic blood pressure ,night 24 h systolic blood pressure variability ,daytime blood pressure variability ,daytime diastolic blood pressure variability ,nocturnal systolic blood pressure variability was lower than control group. Conclusion ：Simvastatin combined with amlodipine can effec- tively decrease blood pressure ,adjusting blood lipid ,and significantly improved in patients with essential hypertension blood pressure variability.