环磷腺苷葡胺治疗慢性充血性心力衰竭的临床研究

Clinical research of adenosine cyclophosphate glucosamine on chronic heart failure

目的探讨环磷腺苷葡胺对慢性充血性心力衰竭的治疗效果。方法将84例慢性心力衰竭(CHF)患者随机分为治疗组和对照组,每组42例。对照组给予常规抗心衰治疗,治疗组在对照组的基础上加用环磷腺苷葡胺180 mg,1次/d静点,持续12 d。对比分析两组的临床疗效。结果两组治疗后心功能均明显改善。治疗后,治疗组的LVEF、CI、BNP明显好于对照组(P<0.05),而HR、BP、SV、CO与对照组比较差异无统计学意义(P>0.05)。结论在传统治疗的基础上加用环磷腺苷葡胺,可以显著提高CHF的临床疗效,但不能改善心脏重构的病理变化。

Objective To assess the efficacy of adenosine cyclophosphate glucosamine in treating chronic con-gestive heart failure. Methods 84 patients with chronic congestive heart failure were randomly divide into study group （treated with adenosine cyclophosphate glucosamine 180 mg/d iv drop and routine therapy for 12 d）and control group （ treated with routine therapy only for 12 d）. After the treatment, the clinical efficacy of the two groups were compared. Results The cardiac functions of the two groups were both improved after treatment. The indexes such as LVEF, CI, BNP of study group were better than those of control group （P 〈 0. 05 ） ; However, there were no difference in HR, BP, SV, CO between the two groups （ P 〉 0. 05 ）. Conclusion Adenosine cyclophosphate glucomine can significantly im-prove the efficacy in treating chronic congestive heart failure, but it can not ameliorate the cardiac reconstitution due to its pharmacological mechanism.