妊娠妇女产前感染4项检测结果分析

Analysis of detection result of four prenatal infection markers of pregnant women

目的了解妊娠妇女产前乙型肝炎、丙型肝炎、梅毒和人类免疫缺陷病毒抗体(抗-HIV1/2)4项检测结果。方法乙型肝炎病毒、丙型肝炎病毒(HCV)标志物、抗-HIV1/2筛查均采用酶联免疫吸附试验检测、梅毒检测采用快速血浆反应素环状卡试验(RPR),RPR阳性再做梅毒螺旋体抗体明胶颗粒凝集试验(TPPA),抗-HIV1/2筛查阳性反应标本送江西省疾病预防控制中心艾滋病确认实验室进行免疫印迹WB确认试验。结果 2 187例孕妇中乙型肝炎表面抗原阳性最高,137例,占6.26%,其次是抗-HCV阳性19例,占0.87%,RPR和TPPA阳性4例,占0.18%;未检出抗-HIV1/2阳性者,HBV-M分布模式和交叉感染各异。结论孕妇产前感染4项检测为阻断和降低上述感染性疾病的母婴传播、避免医疗纠纷、预防医院感染。

Objective To investigate prenatal hepatitis B, hepatitis C,syphilis and antibody to human immunodeficiency virus（anti-HIV1/2） test results of pregnant women. Methods Hepatitis B, hepatitis C,anti-HIV1/2 were tested by screening enzyme-linked immunosorbent assay （ELSIA）, syphilis was tested by rapid plasma reagin card test ring （RPR）, RPR positive samples were did the treponema pallidum antibodies gelatin particle agglutination test （TPPA）, anti HIV1/2 screening positive samples were sent to J iangxi disease AIDS Prevention and Control Center to do tbe WB Western blot test to confirm. Results Among the 2 187 cases of pregnant wome,137 cases were HBsAg- positive, accounted for 6.26 %, followed by anti-HCV positive in 19 cases, accounted for 0.87 %, RPR and TPPA positive in 4 cases,accounted for 0. 18 %; No detection of anti-HIV1/2 positive case was found,and there were difference between HBV-M distribution patterns and cross infection. Conclusion Prenatal detection of four infection markers maybe block and reduce the spread of infectious diseases through mother-to-child transmission,and prevent medical disputes and nosocomial infections.