转录因子NF-E2相关因子2-抗氧化反应元件信号路径及其肝脏保护作用进展

Nuclear factor erythroid 2-related factor 2-antioxidant response element signal path and the protective effect on liver

背景随着肝脏外科手术尤其是肝脏移植手术的发展，以转录因子NF-E2相关因子2（nuclearfactorerythroid2-relatedfactor2，Nrf2）与抗氧化反应元件（antioxidantresponseelement，ARE）抗氧化应激系统在肝脏损伤中的作用倍受关注。目的分析并总结Nrf2-ARE抗氧化系统在肝脏保护各方面的文献资料。内容简要介绍Nrf2，ARE的结构及其信号路径；综述了Nrf2基因缺失、Nrf2药物激活、Nrf2基因激活3类模型小鼠与野生小鼠肝脏对氧化应激的耐受性比较的结果。趋向Nrf2-ARE信号路径在肝脏中有一定的保护作用，为临床提供了新的思路。

Background With the development of liver surgery, especially in the liver transplants, more attention was focus on the transcription factor NF-E2-related factor 2 （nuclear factor elytroid 2-related factor 2, Nrf2） and antioxidant response element （ARE） anti-oxidative stress system effect on the liver injury. Objective Literatures about the Nrf2-ARE antioxidant system protection in the liver were analyzed and summarized. Content Nrf2, ARE structure and the signal path and comparisons of three kinds of model mice-Nrf2 gene deletion, Nrf2 drugs activation, Nrf2 gene activation-with wild-type mice on liver tolerance to oxidative stress were briefly reviewed. Trend Nrf2-ARE signaling pathway in the liver has a protective effec for clinical application.