摘要
磷脂酰肌醇蛋白多糖(GPC)-3相关信号通路与肝细胞癌(HCC)发生发展密切相关。GPC-3除用于HCC特异诊断外,靶向GPC-3可明显抑制HCC细胞增殖并诱导凋亡,有望成为HCC的分子靶目标。
Glypican - 3 （ GPC - 3 ） signaling pathways contribute to the development and progression of hepatocellular carcinoma （HCC）. As a specific diagnostic marker of HCC, GPC - 3 may also represent a novel therapeutic target. Recent studies have shown that molecular targeting of GPC - 3 can significantly inhibit growth of HCC cells, as well as enhance apoptosis. Here, we discuss the underlying mechanisms of the GPC - 3 - mediated anti - proliferative and pro - apoptotic effects in HCC, which may help in development of improved GPC - 3 targeted therapy.
出处
《临床肝胆病杂志》
CAS
2013年第1期77-81,共5页
Journal of Clinical Hepatology
基金
江苏省卫生科技项目(H2009025)
南通市社会事业创新与示范计划项目(HS2011012)
关键词
肝肿瘤
醇类
liver neoplasms
phosphatidylinositols
