血清可溶性凝集素样氧化型低密度脂蛋白受体-1水平与男性吸烟者合并冠心病的相关性研究

Correlation of serum sLOX-1 levels with the presence of coronary artery disease in smokers

目的探讨血清可溶性凝集素样氧化型低密度脂蛋白受体-1（sLOX-1）水平与男性吸烟者合并冠心病相关性。方法该研究共纳人216例男性吸烟者，根据患者是否合并冠心病将所有患者分为冠心病组（n=95）及非冠心病组（n=121），比较两组的血清sLOX-1水平，通过Logistic回归分析评价血清sLOX-1水平与合并冠心病的相关性。结果冠心病组患者血清sLOX-1水平（678～2104ng／L，平均1652ng／L）显著高于非冠心病组患者（382～1334ng／L，平均829ng／L）（P〈0．01）。多元Logistic回归分析显示血清sLOX-1水平与男性吸烟者合并冠心病存在正相关性（优势比为2．136，95％可信区间为1．227～3．401，P〈0．01）。结论高血清sLOX-1水平是男性吸烟者罹患冠心病的独立危险因子，检测血清sLOX-1水平可能成为预测男性吸烟者合并冠心病风险的一种重要的手段。

Objective To explore whether serum soluble lectin-like oxidized low-density lipoprotein receptor-1 （sLOX-1） levels are associated with the presence of coronary artery disease in male smokers. Methods 216 male smokers were enrolled in this cross-sectional study. All the smokers were divided into coronary artery disease group （n = 95） and patients without CAD （not-CAD group, n = 121） based on the presence of coronary artery disease or not. Serum sLOX-1 levels were compared between the two groups. The correlation between serum sLOX-1 levels and the presence of coronary artery disease was investigated by Logistic analysis. Results Serum sLOX-1 levels were signifi- cantly higher in CAD group than those in not-coronary artery disease group [（678-2 104 ng/L, average 1 652 ng/L） vs （382-1 334 ng/L, average 829 ng/L）], P 〈 0.01）. Multiple Logistic analysis showed that serum sLOX-1 levels were independently associated with the presence of Coronary artery disease （odds ratio： 2.136, 95% confidence interval： 1.227-3.401, P 〈 0.01）. Conclusion Higher serum sLOX-1 levels is an independent risk factor for the presence of coronary artery disease in male smokers. The determination of serum sLOX-1 levels might be a useful method for pre- dicting the risk of coronary artery disease in male smokers.