非酒精性脂肪肝与动脉粥样硬化危险因素相关性调查

Investigation of correlation between non-alcoholic fatty liver and risk factors of atherosclerosis

目的探讨新疆油田职工非酒精性脂肪肝（NAFLD）患病率及其与动脉粥样硬化危险因素的相关性。方法选择2010年12月～2011年12月在明周石油医院进行职工体检者705人，询问病史、吸烟史等，监测血压，测量身高、体重，行腹部超声及血脂、血糖、肝肾功能等生化检查，将其分为NAFLD组及对照组，进行组间对比分析。结果705名入选者，检出NAFLD286例，检卅率为40．6％。NAFLD组患者血三酰甘油、胆固醇水平高于对照组，高密度脂蛋白胆固醇水平低于对照组，差异有统计学意义（P〈0．05或P〈0．01）。NAFLD组合并高血压、糖尿病和糖耐量异常、超重、吸烟者的比例分别为34．3％、30．4％、39．2％、36．3％；对照组为15．5％、10．3％、12．4％、18．6％，两组差异有统计学意义（均P〈0．05）。结论新疆油田职工NAFLD的患病率高于一般人群；NAFLD与动脉硬化有关。

Objective To investigate the prevalence of non-alcoholic fatty liver （NAFLD） in Xinjiang oil field worker and its relationshiop with risk factors of atherosclerosis. Methods 705 physical examination workers in Mingyuan oil hospital were selected from December 2010 to December 2011. All patients were asked about medical history and smoking history, blood pressure was monitored, height and weight were measured, and abdominal ultrasound, biochemi- cal test of blood lipid, blood sugar, hepatic and renal function were carried out. All patients were divided into the NAFLD group and the control group, the indexes between the two groups were analyzed. Results Among 705 worker, there were 286 people diagnosed with NAFLD, the detection rate was 40.6%. In NAFLD group, levels of triglycerides and cholesterol were higher than those of the control group, high density lipoprotein cholesterol was lower than that of the control group, the differences were statistically significant （P 〈 0.05 or P 〈 0.01）. The proportions of patients com- bined with high blood pressure, diabetes and impaired glucose tolerance abnormalities, overweight and smoking in the NAFLD group were 34.3%, 30.4%, 39.2%, 36.3% respectively, which in the control group were 15.5%, 10.3%, 12.4%, 18.6% respectively, the differences were statistically significant （all P 〈 0.05）. Conclusion The prevalence of NAFLD in oil field workers is higher than general population, and NAFLD is correlated with atherosclerosis.