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以D-葡萄糖为载体的布洛芬脑靶向前体药物的设计与合成 被引量：2

Design and synthesis of Ibuprofen prodrugs for brain target delivery using D-glucose as a vector
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摘要 目的设计并合成以葡萄糖转运体为靶细胞的脑靶向前体药物。方法将非甾体抗炎药布洛芬通过不同的桥链(1,6-己二醇和1,12-十二二醇)与D-葡萄糖通过共价键连接起来。结果成功合成了两个以D-葡萄糖为载体的脑靶向前体药物。结论目标化合物已经1HNMR、MS确证。 OBJECTIVE To design and synthesize brain targeting prodrugs utilizing the transporter of GLUT1.METHODS The ibuprofen and D-glucose were covalently linked together by the bridge chain of 1,6-hexanediol and 1,12-dodecanediol.RESULTS Brain targeting prodrugs were designed and synthesized.CONCLUSION The chemical structure of the target compounds and intermedium were confirmed by 1HNMR and MS.
作者 刘兴 李文浩 龚涛
机构地区 四川大学华西药学院靶向药物与释药系统教育部重点实验室
出处 《华西药学杂志》 CAS CSCD 北大核心 2013年第1期26-28,共3页 West China Journal of Pharmaceutical Sciences
关键词 脑靶向 D-葡萄糖 非甾体抗炎药 合成 Brain targeting D-glucose NSAIDs Synthesis
分类号 R914 [医药卫生—药物化学]
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参考文献6

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同被引文献18

  • 1赵秀丽,陈大为,李可欣,王丹蕾,罗轶凡.布洛芬丁香酚酯前体药物的合成及其水解动力学[J].沈阳药科大学学报,2006,23(2):70-73. 被引量：7
  • 2赵秀丽,陈大为,乔明曦,胡海洋,李磊.布洛芬丁香酚酯微乳的镇痛作用及大鼠体内药动学研究[J].中国新药杂志,2007,16(15):1178-1182. 被引量：3
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华西药学杂志
2013年 第1期

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