PT多肽修饰的地塞米松纳米脂质载体的体外释放研究

Study on the release characteristics of PT peptide grafted Dexamethasone nanostructured lipid carriers in vitro

目的研究PT多肽修饰的地塞米松纳米脂质载体的体外释放规律。方法选用pH7.4磷酸盐缓冲液作为释药介质,测定并绘制其体外释放曲线,并拟合释药数据。结果 PT多肽修饰的地塞米松纳米脂质载体在0.5 h的突释率为24.2%,24h药物累计释放量为88%,最佳拟合模型为Weibull方程。结论 PT多肽修饰的地塞米松纳米脂质载体的体外释放突释效应减少,具有缓释效应。

OBJECTIVE To study the release characteristics of PT peptide grafted dexamethasone nanostructured lipid carriers in vitro.METHODS Phosphate buffer（pH7.4） was chosen as the release medium.The characteristics of in vitro release were investigated and simulated by regression equation.RESULTS The initial release rate in 0.5 h and the accumulation release rate in 24 h of PT peptide grafted dexamethasone nanostructured lipid carriers in vitro were 24.2% and 88%,respectively.The data was best fitted with Weibull equation.CONCLUSION Sustained-release effect is the release characteristic of PT peptide grafted dexamethasone nanostructured lipid carriers in vitro,and its burst-release effect is declined.