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cAMP对缺血神经元保护作用的机制研究 被引量：3

Mechanism of cAMP in Ischemic Neuron Protection
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摘要 目前对于缺血性脑卒中后神经元的保护仍缺乏明确有效的药物治疗。磷酸二酯酶抑制剂可通过增加细胞内cAMP的含量对缺血性神经元发挥保护作用。本文从cAMP对缺血性神经元胞内和胞外的作用,阐述cAMP对缺血神经元发挥保护作用的机制,并试图为磷酸二酯酶抑制剂等cAMP增效药物的临床应用提供理论基础。 Current researches and trials witness the lack of effective treatment in neuron protection after stroke. Yet phosphodiesterase inhibitors present protective effect in ischemic neuron in an intracellular cAMP enhancing pattern. The protective mechanism of cAMP in ischemic neuron after stroke was discussed. And the evidences for therapeutic utilization of phosphodiesterase inhibitors were offered.
作者 乌日罕 赵延欣 刘学源
机构地区 同济大学医学院附属上海市第十人民医院神经内科
出处 《中国临床神经科学》 2013年第1期93-97,共5页 Chinese Journal of Clinical Neurosciences
关键词 缺血神经元 环磷酸腺苷 磷酸二酯酶抑制剂 保护作用 腺苷 CD39 CD73 ischemic neuron cAMP phosphodiesterase inhibitor protection adenosine CD39 CD73
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献29

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中国临床神经科学
2013年 第1期

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